PPR { RETE|ID 1 FBpp0085439 SYM 1 1.28-PA AAL 1 217 PSZ 1 - HG 1 - DBA 1 - REF 1 1 DT 1 5 Jun 2004 RESZ 323 ID|FBpp0085439 SYM|1.28-PA SYN|CG9397-PA ASAL|FBal0066314==1.28+ DT|5 Jun 2004 |5 Jun 2004 ASGN|FBgn0010347==1.28 REFDSR { RDID|FBrf0166453 |FlyBase Genome Annotators |2004 AAL|217 ASTR|FBtr0086103==1.28-RA } REF { REFM|FBrf0166453 |FlyBase Genome Annotators |2004 } } # EOR PPR { RETE|ID 1 FBpp0000001 SYM 1 1.28+P217 AAL 1 217 PSZ 1 22 HG 1 - DBA 1 + REF 1 2 DT 1 4 Feb 1998 RESZ 435 ID|FBpp0000001 SYM|1.28+P217 ASAL|FBal0066314==1.28+ DT|4 Feb 1998 |4 Feb 1998 ASGN|FBgn0010347==1.28 REFDSR { RDID|FBrf0064596 |Mahaffey et al. |1993 AAL|217 PSZ|22 | predicted ASTR|FBtr0000715==1.28+R2.1 } REFDSR { RDID|FBrf0105495 |FlyBase |1992- DBA|NA:L07262 |PA:AAA03084 } REF { REFM|FBrf0064596 |Mahaffey et al. |1993 REFM|FBrf0105495 |FlyBase |1992- } } # EOR PPR { RETE|ID 1 FBpp0003194 SYM 1 3-oxoacid-CoA-transferase+PA AAL 1 - PSZ 1 - HG 1 + DBA 1 - REF 1 1 DT 1 22 Aug 2000 RESZ 516 ID|FBpp0003194 SYM|3-oxoacid-CoA-transferase+PA ASAL|FBal0099791==3-oxoacid-CoA-transferase+ DT|22 Aug 2000 |22 Aug 2000 ASGN|FBgn0027933==3-oxoacid-CoA-transferase REFDSR { RDID|FBrf0110051 |Kasravi et al. |1999 HG|Pig | FBgn0027933==3-oxoacid-CoA-transferase |C. elegans | FBgn0027933==3-oxoacid-CoA-transferase ASTR|FBtr0006078==3-oxoacid-CoA-transferase+R1.8 } REF { REFM|FBrf0110051 |Kasravi et al. |1999 } } # EOR PPR { RETE|ID 1 FBpp0000006 SYM 1 5-HT1A-P1 AAL 1 834 PSZ 1 - HG 1 - DBA 1 + REF 1 3 DT 1 5 Jun 2001 RESZ 835 ID|FBpp0000006 SYM|5-HT1A-P1 SYN|5-HT1A+P834 ASAL|FBal0071518==5-HT1A+ DT|5 Jun 2001 |4 Feb 1998 ARGS|FBgn0004168 DARTS|FBtr0086578 ASGN|FBgn0004168==5-HT1A REFDSR { RDID|FBrf0055969 |Saudou et al. |1992 AAL|834 ASTR|FBtr0086578==5-HT1A-RA CC|When expressed in Cos-7 cells, FBgn0004168==5-HT1A receptors display a high affinity | for the non-specific serotoninergic ligand LSD. FBgn0004168==5-HT1A receptors inhibit | adenylate cyclase and activate phospholipase C. } REFDSR { RDID|FBrf0104946 |FlyBase |1996- ASTR|FBtr0086578==5-HT1A-RA } REFDSR { RDID|FBrf0105495 |FlyBase |1992- DBA|NA:Z11489 |PA:CAA77570 } REF { REFM|FBrf0055969 |Saudou et al. |1992 REFM|FBrf0104946 |FlyBase |1996- REFM|FBrf0105495 |FlyBase |1992- } } # EOR PPR { RETE|ID 1 FBpp0085762 SYM 1 5-HT1A-PA AAL 1 834 PSZ 1 - HG 1 - DBA 1 - REF 1 1 DT 1 5 Jun 2004 RESZ 289 ID|FBpp0085762 SYM|5-HT1A-PA SYN|CG16720-PA ASAL|FBal0071518==5-HT1A+ DT|5 Jun 2004 |5 Jun 2004 ASGN|FBgn0004168==5-HT1A REFDSR { RDID|FBrf0166453 |FlyBase Genome Annotators |2004 AAL|834 } REF { REFM|FBrf0166453 |FlyBase Genome Annotators |2004 } } # EOR PPR { RETE|ID 1 FBpp0085761 SYM 1 5-HT1A-PB AAL 1 834 PSZ 1 - HG 1 - DBA 1 - REF 1 1 DT 1 5 Jun 2004 RESZ 332 ID|FBpp0085761 SYM|5-HT1A-PB SYN|CG16720-PB ASAL|FBal0071518==5-HT1A+ DT|5 Jun 2004 |5 Jun 2004 ASGN|FBgn0004168==5-HT1A REFDSR { RDID|FBrf0166453 |FlyBase Genome Annotators |2004 AAL|834 ASTR|FBtr0086577==5-HT1A-RB } REF { REFM|FBrf0166453 |FlyBase Genome Annotators |2004 } } # EOR PPR { RETE|ID 1 FBpp0085783 SYM 1 5-HT1B-PA AAL 1 474 PSZ 1 - HG 1 - DBA 1 - REF 1 1 DT 1 5 Jun 2004 RESZ 332 ID|FBpp0085783 SYM|5-HT1B-PA SYN|CG15113-PA ASAL|FBal0071519==5-HT1B+ DT|5 Jun 2004 |5 Jun 2004 ASGN|FBgn0004572==5-HT1B REFDSR { RDID|FBrf0166453 |FlyBase Genome Annotators |2004 AAL|474 ASTR|FBtr0086599==5-HT1B-RA } REF { REFM|FBrf0166453 |FlyBase Genome Annotators |2004 } } # EOR PPR { RETE|ID 1 FBpp0000007 SYM 1 5-HT1B+P645 AAL 1 645 PSZ 1 - HG 1 - DBA 1 + REF 1 2 DT 1 4 Feb 1998 RESZ 676 ID|FBpp0000007 SYM|5-HT1B+P645 ASAL|FBal0071519==5-HT1B+ DT|4 Feb 1998 |4 Feb 1998 ASGN|FBgn0004572==5-HT1B REFDSR { RDID|FBrf0055969 |Saudou et al. |1992 AAL|645 ASTR|FBtr0002288==5-HT1B+R4.9 CC|When expressed in Cos-7 cells, FBgn0004572==5-HT1B receptors display a high affinity | for the non-specific serotoninergic ligand LSD. FBgn0004572==5-HT1B receptors inhibit | adenylate cyclase and activate phospholipase C. } REFDSR { RDID|FBrf0105495 |FlyBase |1992- DBA|NA:Z11490 |PA:CAA77571 } REF { REFM|FBrf0055969 |Saudou et al. |1992 REFM|FBrf0105495 |FlyBase |1992- } } # EOR PPR { RETE|ID 1 FBpp0078494 SYM 1 5-HT2-PA AAL 1 868 PSZ 1 - HG 1 - DBA 1 - REF 1 1 DT 1 5 Jun 2004 RESZ 327 ID|FBpp0078494 SYM|5-HT2-PA SYN|CG1056-PA ASAL|FBal0066320==5-HT2+ DT|5 Jun 2004 |5 Jun 2004 ASGN|FBgn0013743==5-HT2 REFDSR { RDID|FBrf0166453 |FlyBase Genome Annotators |2004 AAL|868 ASTR|FBtr0078854==5-HT2-RA } REF { REFM|FBrf0166453 |FlyBase Genome Annotators |2004 } } # EOR PPR { RETE|ID 1 FBpp0078495 SYM 1 5-HT2-PB AAL 1 930 PSZ 1 - HG 1 - DBA 1 - REF 1 1 DT 1 5 Jun 2004 RESZ 327 ID|FBpp0078495 SYM|5-HT2-PB SYN|CG1056-PB ASAL|FBal0066320==5-HT2+ DT|5 Jun 2004 |5 Jun 2004 ASGN|FBgn0013743==5-HT2 REFDSR { RDID|FBrf0166453 |FlyBase Genome Annotators |2004 AAL|930 ASTR|FBtr0078855==5-HT2-RB } REF { REFM|FBrf0166453 |FlyBase Genome Annotators |2004 } } # EOR PPR { RETE|ID 1 FBpp0000008 SYM 1 5-HT2+P868 AAL 1 868 PSZ 1 - HG 1 - DBA 1 + REF 1 2 DT 1 4 Feb 1998 RESZ 598 ID|FBpp0000008 SYM|5-HT2+P868 ASAL|FBal0066320==5-HT2+ DT|4 Feb 1998 |4 Feb 1998 ASGN|FBgn0013743==5-HT2 REFDSR { RDID|FBrf0081644 |Colas et al. |1995 AAL|868 ASTR|FBtr0001214==5-HT2+R3.9 CC|FBgn0013743==5-HT2 protein displays pharmacological properties typical of the mammalian | 5-HT[[2]] serotonin receptor subtype. It is detected in embryonic extracts. } REFDSR { RDID|FBrf0105495 |FlyBase |1992- DBA|NA:X81835 |PA:CAA57429 } REF { REFM|FBrf0081644 |Colas et al. |1995 REFM|FBrf0105495 |FlyBase |1992- } } # EOR PPR { RETE|ID 1 FBpp0085108 SYM 1 5-HT7-PA AAL 1 564 PSZ 1 - HG 1 - DBA 1 - REF 1 1 DT 1 5 Jun 2004 RESZ 328 ID|FBpp0085108 SYM|5-HT7-PA SYN|CG12073-PA ASAL|FBal0071517==5-HT7+ DT|5 Jun 2004 |5 Jun 2004 ASGN|FBgn0004573==5-HT7 REFDSR { RDID|FBrf0166453 |FlyBase Genome Annotators |2004 AAL|564 ASTR|FBtr0085746==5-HT7-RA } REF { REFM|FBrf0166453 |FlyBase Genome Annotators |2004 } } # EOR PPR { RETE|ID 1 FBpp0000009 SYM 1 5-HT7+P564 AAL 1 564 PSZ 1 - HG 1 - DBA 1 + REF 1 3 DT 1 4 Feb 1998 RESZ 1809 ID|FBpp0000009 SYM|5-HT7+P564 ASAL|FBal0071517==5-HT7+ DT|4 Feb 1998 |4 Feb 1998 ASGN|FBgn0004573==5-HT7 REFDSR { RDID|FBrf0052872 |Witz et al. |1990 AAL|564 ASTR|FBtr0002286==5-HT7+R5.5 CC|Analysis of the FBgn0004573==5-HT7 protein sequence reveals the existence of an eighth | hydrophobic domain in addition to the seven normally found in | G-protein-coupled receptors. It is located near the amino terminus and is | long enough to span the cytoplasmic membrane. A Ser-Gly motif is repeated | 10 times in the first putative extracellular domain which shows homology to | rat yolk sac tumor chondroitin sulfate proteoglycan, Drosophila FBgn0003068==per, and | the Neurospora frq gene. This Gly-Ser repeat may serve as an attachment | site for glycosaminoglycans. When stably introduced into mouse NIH 3T3 | cells, the FBgn0004573==5-HT7 receptor activates adenylate cyclase in response to | serotonin and is inhibited by serotonin receptor antagonists. The FBgn0004573==5-HT7 | amino acid sequence shows homology to a number of G-protein-coupled | receptors in the putative transmembrane domains and at their borders but | not in the amino- and carboxy-terminal tails or in the long third | cytoplasmic loop. } REFDSR { RDID|FBrf0055969 |Saudou et al. |1992 CC|When expressed in Cos-7 cells, FBgn0004573==5-HT7 receptors display a high affinity for | the non-specific serotoninergic ligand LSD. FBgn0004573==5-HT7 receptors activate | adenylate cyclase. } REFDSR { RDID|FBrf0105495 |FlyBase |1992- DBA|NA:M55533 |PA:AAA28305 } REF { REFM|FBrf0052872 |Witz et al. |1990 REFM|FBrf0055969 |Saudou et al. |1992 REFM|FBrf0105495 |FlyBase |1992- } } # EOR PPR { RETE|ID 1 FBpp0078435 SYM 1 7B2-PA AAL 1 271 PSZ 1 - HG 1 - DBA 1 - REF 1 1 DT 1 5 Jun 2004 RESZ 319 ID|FBpp0078435 SYM|7B2-PA SYN|CG1168-PA ASAL|FBal0116908==7B2+ DT|5 Jun 2004 |5 Jun 2004 ASGN|FBgn0041707==7B2 REFDSR { RDID|FBrf0166453 |FlyBase Genome Annotators |2004 AAL|271 ASTR|FBtr0078789==7B2-RA } REF { REFM|FBrf0166453 |FlyBase Genome Annotators |2004 } } # EOR PPR { RETE|ID 1 FBpp0082987 SYM 1 14-3-3&egr;-PA AAL 1 262 PSZ 1 - HG 1 - DBA 1 - REF 1 1 DT 1 5 Jun 2004 RESZ 352 ID|FBpp0082987 SYM|14-3-3&egr;-PA SYN|CG31196-PA DT|5 Jun 2004 |5 Jun 2004 ASGN|FBgn0020238==14-3-3&egr; ASAL|FBal0079281==14-3-3&egr;+ REFDSR { RDID|FBrf0166453 |FlyBase Genome Annotators |2004 AAL|262 ASTR|FBtr0083565==14-3-3&egr;-RA } REF { REFM|FBrf0166453 |FlyBase Genome Annotators |2004 } } # EOR PPR { RETE|ID 1 FBpp0082988 SYM 1 14-3-3&egr;-PB AAL 1 261 PSZ 1 - HG 1 - DBA 1 - REF 1 1 DT 1 5 Jun 2004 RESZ 352 ID|FBpp0082988 SYM|14-3-3&egr;-PB SYN|CG31196-PB DT|5 Jun 2004 |5 Jun 2004 ASGN|FBgn0020238==14-3-3&egr; ASAL|FBal0079281==14-3-3&egr;+ REFDSR { RDID|FBrf0166453 |FlyBase Genome Annotators |2004 AAL|261 ASTR|FBtr0083566==14-3-3&egr;-RB } REF { REFM|FBrf0166453 |FlyBase Genome Annotators |2004 } } # EOR PPR { RETE|ID 1 FBpp0082989 SYM 1 14-3-3&egr;-PC AAL 1 256 PSZ 1 - HG 1 - DBA 1 - REF 1 1 DT 1 5 Jun 2004 RESZ 352 ID|FBpp0082989 SYM|14-3-3&egr;-PC SYN|CG31196-PC DT|5 Jun 2004 |5 Jun 2004 ASGN|FBgn0020238==14-3-3&egr; ASAL|FBal0079281==14-3-3&egr;+ REFDSR { RDID|FBrf0166453 |FlyBase Genome Annotators |2004 AAL|256 ASTR|FBtr0083567==14-3-3&egr;-RC } REF { REFM|FBrf0166453 |FlyBase Genome Annotators |2004 } } # EOR PPR { RETE|ID 1 FBpp0082990 SYM 1 14-3-3&egr;-PD AAL 1 260 PSZ 1 - HG 1 - DBA 1 - REF 1 1 DT 1 5 Jun 2004 RESZ 352 ID|FBpp0082990 SYM|14-3-3&egr;-PD SYN|CG31196-PD DT|5 Jun 2004 |5 Jun 2004 ASGN|FBgn0020238==14-3-3&egr; ASAL|FBal0079281==14-3-3&egr;+ REFDSR { RDID|FBrf0166453 |FlyBase Genome Annotators |2004 AAL|260 ASTR|FBtr0083568==14-3-3&egr;-RD } REF { REFM|FBrf0166453 |FlyBase Genome Annotators |2004 } } # EOR PPR { RETE|ID 1 FBpp0002696 SYM 1 14-3-3&egr;+P260 AAL 1 260 PSZ 1 30 HG 1 + DBA 1 + REF 1 2 DT 1 13 Sep 1999 RESZ 1883 ID|FBpp0002696 SYM|14-3-3&egr;+P260 ASAL|FBal0079281==14-3-3&egr;+ DT|13 Sep 1999 |13 Sep 1999 ASGN|FBgn0020238==14-3-3&egr; REFDSR { RDID|FBrf0093395 |Chang and Rubin |1997 AAL|260 HG|Homo sapiens | 14-3-3epsilon (U54778) DBA|NA:U84897 |PA:AAC47519 ASTR|FBtr0004963==14-3-3&egr;+R1.5 } REFDSR { RDID|FBrf0108031 |Tien et al. |1999 PSZ|30 | observed ABOD|polyclonal BODP|In syncytial embryos, 14-3-3&egr; protein localizes to rapidly dividing | nuclei. During mitosis, it is retained in nuclei. During cellularization, | nuclear expression diminishes and membrane expression appears. During | gastrulation, a low level of staining is observed in ectodermal cells. High | levels are transiently observed in various tissues. At stages 7 and 8, | expression is observed in several invaginating furrows, the ventral midline | cells, and the dorsal epidermal cells. At stages 9 and 10, prominant | staining is observed in the ventral neurogenic region extending in a 4-5 | cell wide region from the midline. 14-3-3&egr; protein is highly enriched | in the central and peripheral nervous systems. It is observed in the | cytoplasm of neurons. ASM|immunolocalization CVBODP|immunolocalization | E | syncytial blastoderm

| E | stage 7,8 cephalic furrow

| E | stage 7,8 anterior transverse furrow

| E | stage 7,8 posterior transverse furrow

| E | stage 7,8 amnioproctodeal invagination

| E | stage 7,8 dorsal ectoderm

| E | stage 7,8 ventral midline

| E | stage 9,10 ventral neurectoderm

| E embryonic central nervous system

| E embryonic peripheral nervous system

CVCEL|nucleus |cytoplasm } REF { REFM|FBrf0093395 |Chang and Rubin |1997 REFM|FBrf0108031 |Tien et al. |1999 } } # EOR PPR { RETE|ID 1 FBpp0000003 SYM 1 14-3-3&zgr;-P1 AAL 1 248 PSZ 1 29 HG 1 - DBA 1 + REF 1 5 DT 1 4 Feb 2000 RESZ 1318 ID|FBpp0000003 SYM|14-3-3&zgr;-P1 SYN|14-3-3zeta+P248 |14-3-3+P248 ASAL|FBal0066544==14-3-3&zgr;+ DT|4 Feb 2000 |4 Feb 1998 ID2|FBpp0002023 ARGS|FBgn0004907 DARTS|FBtr0002132 |FBtr0004966 ASGN|FBgn0004907==14-3-3&zgr; REFDSR { RDID|FBrf0056086 |Swanson and Ganguly |1992 AAL|248 ASTR|FBtr0002132==14-3-3&zgr;-RE |FBtr0002133==14-3-3&zgr;+R1.9 |FBtr0002134==14-3-3&zgr;-RA } REFDSR { RDID|FBrf0090801 |Skoulakis and Davis |1996 AAL|248 PSZ|29 | observed ABOD|polyclonal ASTR|FBtr0002132==14-3-3&zgr;-RE |FBtr0002133==14-3-3&zgr;+R1.9 |FBtr0002134==14-3-3&zgr;-RA } REFDSR { RDID|FBrf0093549 |Kockel et al. |1997 AAL|248 DBA|NA:Y12573 |PA:CAA73153 ASTR|FBtr0002132==14-3-3&zgr;-RE |FBtr0004966==14-3-3&zgr;-RD } REFDSR { RDID|FBrf0104946 |FlyBase |1996- ASTR|FBtr0002132==14-3-3&zgr;-RE |FBtr0004966==14-3-3&zgr;-RD } REFDSR { RDID|FBrf0105495 |FlyBase |1992- DBA|NA:M77518 |PA:AAA28324 } REF { REFM|FBrf0056086 |Swanson and Ganguly |1992 REFM|FBrf0090801 |Skoulakis and Davis |1996 REFM|FBrf0093549 |Kockel et al. |1997 REFM|FBrf0104946 |FlyBase |1996- REFM|FBrf0105495 |FlyBase |1992- } } # EOR PPR { RETE|ID 1 FBpp0002710 SYM 1 14-3-3&zgr;-P2 AAL 1 248 PSZ 1 - HG 1 - DBA 1 + REF 1 2 DT 1 4 Feb 2000 RESZ 704 ID|FBpp0002710 SYM|14-3-3&zgr;-P2 ASAL|FBal0066544==14-3-3&zgr;+ DT|4 Feb 2000 |13 Sep 1999 ARGS|FBgn0004907 DARTS|FBtr0002134 |FBtr0004964 |FBtr0004965 ASGN|FBgn0004907==14-3-3&zgr; REFDSR { RDID|FBrf0093549 |Kockel et al. |1997 AAL|248 DBA|NA:Y12573 |PA:CAA73152 ASTR|FBtr0002134==14-3-3&zgr;-RA |FBtr0004964==14-3-3&zgr;-RB |FBtr0004965==14-3-3&zgr;-RC } REFDSR { RDID|FBrf0104946 |FlyBase |1996- ASTR|FBtr0002134==14-3-3&zgr;-RA |FBtr0004964==14-3-3&zgr;-RB |FBtr0004965==14-3-3&zgr;-RC } REF { REFM|FBrf0093549 |Kockel et al. |1997 REFM|FBrf0104946 |FlyBase |1996- } } # EOR PPR { RETE|ID 1 FBpp0087501 SYM 1 14-3-3&zgr;-PA AAL 1 248 PSZ 1 - HG 1 - DBA 1 - REF 1 1 DT 1 5 Jun 2004 RESZ 352 ID|FBpp0087501 SYM|14-3-3&zgr;-PA SYN|CG17870-PA DT|5 Jun 2004 |5 Jun 2004 ASGN|FBgn0004907==14-3-3&zgr; ASAL|FBal0066544==14-3-3&zgr;+ REFDSR { RDID|FBrf0166453 |FlyBase Genome Annotators |2004 AAL|248 ASTR|FBtr0088413==14-3-3&zgr;-RA } REF { REFM|FBrf0166453 |FlyBase Genome Annotators |2004 } } # EOR PPR { RETE|ID 1 FBpp0087500 SYM 1 14-3-3&zgr;-PB AAL 1 248 PSZ 1 - HG 1 - DBA 1 - REF 1 1 DT 1 5 Jun 2004 RESZ 352 ID|FBpp0087500 SYM|14-3-3&zgr;-PB SYN|CG17870-PB DT|5 Jun 2004 |5 Jun 2004 ASGN|FBgn0004907==14-3-3&zgr; ASAL|FBal0066544==14-3-3&zgr;+ REFDSR { RDID|FBrf0166453 |FlyBase Genome Annotators |2004 AAL|248 ASTR|FBtr0088412==14-3-3&zgr;-RB } REF { REFM|FBrf0166453 |FlyBase Genome Annotators |2004 } } # EOR PPR { RETE|ID 1 FBpp0089338 SYM 1 14-3-3&zgr;-PC AAL 1 248 PSZ 1 - HG 1 - DBA 1 - REF 1 1 DT 1 5 Jun 2004 RESZ 352 ID|FBpp0089338 SYM|14-3-3&zgr;-PC SYN|CG17870-PC DT|5 Jun 2004 |5 Jun 2004 ASGN|FBgn0004907==14-3-3&zgr; ASAL|FBal0066544==14-3-3&zgr;+ REFDSR { RDID|FBrf0166453 |FlyBase Genome Annotators |2004 AAL|248 ASTR|FBtr0088419==14-3-3&zgr;-RC } REF { REFM|FBrf0166453 |FlyBase Genome Annotators |2004 } } # EOR PPR { RETE|ID 1 FBpp0087502 SYM 1 14-3-3&zgr;-PD AAL 1 248 PSZ 1 - HG 1 - DBA 1 - REF 1 1 DT 1 5 Jun 2004 RESZ 352 ID|FBpp0087502 SYM|14-3-3&zgr;-PD SYN|CG17870-PD DT|5 Jun 2004 |5 Jun 2004 ASGN|FBgn0004907==14-3-3&zgr; ASAL|FBal0066544==14-3-3&zgr;+ REFDSR { RDID|FBrf0166453 |FlyBase Genome Annotators |2004 AAL|248 ASTR|FBtr0088414==14-3-3&zgr;-RD } REF { REFM|FBrf0166453 |FlyBase Genome Annotators |2004 } } # EOR PPR { RETE|ID 1 FBpp0087503 SYM 1 14-3-3&zgr;-PE AAL 1 248 PSZ 1 - HG 1 - DBA 1 - REF 1 1 DT 1 5 Jun 2004 RESZ 352 ID|FBpp0087503 SYM|14-3-3&zgr;-PE SYN|CG17870-PE DT|5 Jun 2004 |5 Jun 2004 ASGN|FBgn0004907==14-3-3&zgr; ASAL|FBal0066544==14-3-3&zgr;+ REFDSR { RDID|FBrf0166453 |FlyBase Genome Annotators |2004 AAL|248 ASTR|FBtr0088415==14-3-3&zgr;-RE } REF { REFM|FBrf0166453 |FlyBase Genome Annotators |2004 } } # EOR PPR { RETE|ID 1 FBpp0087504 SYM 1 14-3-3&zgr;-PF AAL 1 248 PSZ 1 - HG 1 - DBA 1 - REF 1 1 DT 1 5 Jun 2004 RESZ 352 ID|FBpp0087504 SYM|14-3-3&zgr;-PF SYN|CG17870-PF DT|5 Jun 2004 |5 Jun 2004 ASGN|FBgn0004907==14-3-3&zgr; ASAL|FBal0066544==14-3-3&zgr;+ REFDSR { RDID|FBrf0166453 |FlyBase Genome Annotators |2004 AAL|248 ASTR|FBtr0088416==14-3-3&zgr;-RF } REF { REFM|FBrf0166453 |FlyBase Genome Annotators |2004 } } # EOR PPR { RETE|ID 1 FBpp0087505 SYM 1 14-3-3&zgr;-PG AAL 1 248 PSZ 1 - HG 1 - DBA 1 - REF 1 1 DT 1 5 Jun 2004 RESZ 352 ID|FBpp0087505 SYM|14-3-3&zgr;-PG SYN|CG17870-PG DT|5 Jun 2004 |5 Jun 2004 ASGN|FBgn0004907==14-3-3&zgr; ASAL|FBal0066544==14-3-3&zgr;+ REFDSR { RDID|FBrf0166453 |FlyBase Genome Annotators |2004 AAL|248 ASTR|FBtr0088417==14-3-3&zgr;-RG } REF { REFM|FBrf0166453 |FlyBase Genome Annotators |2004 } } # EOR PPR { RETE|ID 1 FBpp0089337 SYM 1 14-3-3&zgr;-PH AAL 1 248 PSZ 1 - HG 1 - DBA 1 - REF 1 1 DT 1 5 Jun 2004 RESZ 352 ID|FBpp0089337 SYM|14-3-3&zgr;-PH SYN|CG17870-PH DT|5 Jun 2004 |5 Jun 2004 ASGN|FBgn0004907==14-3-3&zgr; ASAL|FBal0066544==14-3-3&zgr;+ REFDSR { RDID|FBrf0166453 |FlyBase Genome Annotators |2004 AAL|248 ASTR|FBtr0088418==14-3-3&zgr;-RH } REF { REFM|FBrf0166453 |FlyBase Genome Annotators |2004 } } # EOR PPR { RETE|ID 1 FBpp0002709 SYM 1 14-3-3&zgr;+P AAL 1 - PSZ 1 29 HG 1 - DBA 1 - REF 1 3 DT 1 13 Sep 1999 RESZ 2756 ID|FBpp0002709 SYM|14-3-3&zgr;+P ASAL|FBal0066544==14-3-3&zgr;+ DT|13 Sep 1999 |13 Sep 1999 ASGN|FBgn0004907==14-3-3&zgr; REFDSR { RDID|FBrf0090801 |Skoulakis and Davis |1996 BODP|14-3-3&zgr; protein is abundant in the neuropil of mushroom bodies. It is | detected in the dendritic projections, the cytoplasm of the perikarya, and | the axonal projections that form the peduncle and lobes of mushroom body | neurons. Protein is also detected in the ellipsoid body and a group of | cells thought to be the ring neurons that project to the ellipsoid body. | Staining is also observed in the neuropil and cell bodies of the antennal | lobe. Finally, staining is observed in the thoracic ganglia and in the | cytoplasm of nurse cells and oocytes. ASM|immunolocalization CVBODP|immunolocalization | A mushroom body

| O, A nurse cell

| O, A oocyte

| A thoracic ganglion

| A antennal lobe

| A ellipsoid body

| A ring neuron

} REFDSR { RDID|FBrf0093549 |Kockel et al. |1997 PSZ|29 | observed ABOD|polyclonal PCL|14-3-3&zgr; protein is apically distributed in developing photoreceptor cells. BODP|14-3-3&zgr; protein is expressed in most if not all cells of the eye | imaginal disc. It is enriched in the region posterior to the morphogenetic furrow. CVBODP| L | third instar eye disc

| L | third instar morphogenetic furrow | posterior to

} REFDSR { RDID|FBrf0098203 |Broadie et al. |1997 BODP|14-3-3&zgr; protein is first detected in the nervous system in 16-18hr | embryos. It is observed in cell bodies, axons and synapses, including the | neuromuscular junction. Over the next few hours it is partitioned to the | neuromuscular junctionand lost from the motor axons. By 20 hours, it is | mainly in the synaptic boutons and is barely detectable in axons. In | larvae, 14-3-3&zgr; protein is highly enriched in neuromuscular junction | synaptic boutons. It is found at lower levels in surrounding tissues | including the motor axons and muscle. It is expressed in both type I and | type II neuromuscular junctions. It was found to be enriched in presynaptic boutons. ASM|immunolocalization CVBODP|immunolocalization | E | 16-18hr axon

| E | 16-18hr cell body

| E | late synapse

| E | late neuromuscular junction

| E | 20 hr bouton

| L neuromuscular junction

| L synapse

| L bouton

| L larval muscle system

} REF { REFM|FBrf0090801 |Skoulakis and Davis |1996 REFM|FBrf0093549 |Kockel et al. |1997 REFM|FBrf0098203 |Broadie et al. |1997 } } # EOR PPR { RETE|ID 1 FBpp0000004 SYM 1 18w-P1 AAL 1 1385 PSZ 1 155 HG 1 - DBA 1 + REF 1 4 DT 1 4 Feb 2000 RESZ 824 ID|FBpp0000004 SYM|18w-P1 SYN|18w+P1385 |18w+P1389 ASAL|FBal0066318==18w+ DT|4 Feb 2000 |4 Feb 1998 ID2|FBpp0000005 ARGS|FBgn0004364 DARTS|FBtr0086309 ASGN|FBgn0004364==18w REFDSR { RDID|FBrf0073029 |Eldon et al. |1994 AAL|1389 PSZ|155 | predicted ABOD|polyclonal CVCEL|plasma membrane ASTR|FBtr0086309==18w-RA } REFDSR { RDID|FBrf0076940 |Chiang and Beachy |1994 AAL|1385 ASTR|FBtr0086309==18w-RA } REFDSR { RDID|FBrf0104946 |FlyBase |1996- ASTR|FBtr0086309==18w-RA } REFDSR { RDID|FBrf0105495 |FlyBase |1992- DBA|NA:L23171 |PA:AAA79208 |NA:S76155 |PA:AAB33383 } REF { REFM|FBrf0073029 |Eldon et al. |1994 REFM|FBrf0076940 |Chiang and Beachy |1994 REFM|FBrf0104946 |FlyBase |1996- REFM|FBrf0105495 |FlyBase |1992- } } # EOR PPR { RETE|ID 1 FBpp0085620 SYM 1 18w-PA AAL 1 1385 PSZ 1 - HG 1 - DBA 1 - REF 1 1 DT 1 5 Jun 2004 RESZ 280 ID|FBpp0085620 SYM|18w-PA SYN|CG8896-PA ASAL|FBal0066318==18w+ DT|5 Jun 2004 |5 Jun 2004 ASGN|FBgn0004364==18w REFDSR { RDID|FBrf0166453 |FlyBase Genome Annotators |2004 AAL|1385 } REF { REFM|FBrf0166453 |FlyBase Genome Annotators |2004 } } # EOR PPR { RETE|ID 1 FBpp0075508 SYM 1 26-29kD-proteinase-PA AAL 1 549 PSZ 1 - HG 1 - DBA 1 - REF 1 1 DT 1 5 Jun 2004 RESZ 379 ID|FBpp0075508 SYM|26-29kD-proteinase-PA SYN|CG8947-PA ASAL|FBal0123362==26-29kD-proteinase+ DT|5 Jun 2004 |5 Jun 2004 ASGN|FBgn0028967==26-29kD-proteinase REFDSR { RDID|FBrf0166453 |FlyBase Genome Annotators |2004 AAL|549 ASTR|FBtr0075766==26-29kD-proteinase-RA } REF { REFM|FBrf0166453 |FlyBase Genome Annotators |2004 } } # EOR PPR { RETE|ID 1 FBpp0087084 SYM 1 128up-PA AAL 1 368 PSZ 1 - HG 1 - DBA 1 - REF 1 1 DT 1 5 Jun 2004 RESZ 327 ID|FBpp0087084 SYM|128up-PA SYN|CG8340-PA ASAL|FBal0066316==128up+ DT|5 Jun 2004 |5 Jun 2004 ASGN|FBgn0010339==128up REFDSR { RDID|FBrf0166453 |FlyBase Genome Annotators |2004 AAL|368 ASTR|FBtr0087976==128up-RA } REF { REFM|FBrf0166453 |FlyBase Genome Annotators |2004 } } # EOR PPR { RETE|ID 1 FBpp0000002 SYM 1 128up+P368 AAL 1 368 PSZ 1 41 HG 1 - DBA 1 + REF 1 2 DT 1 4 Feb 1998 RESZ 539 ID|FBpp0000002 SYM|128up+P368 ASAL|FBal0066316==128up+ DT|4 Feb 1998 |4 Feb 1998 ASGN|FBgn0010339==128up REFDSR { RDID|FBrf0067209 |Sommer et al. |1994 AAL|368 PSZ|41 ABOD|polyclonal CVCEL|cytoplasm DBA|NA:X71866 |PA:CAA50701 ASTR|FBtr0000770==128up+R1.6 CC|Bacterially expressed FBgn0010339==128up protein fused to Maltose-binding protein | specifically binds to GTP. } REF { REFM|FBrf0067209 |Sommer et al. |1994 REFM|FBrf0105495 |FlyBase |1992- } } # EOR PPR { RETE|ID 1 FBpp0003610 SYM 1 140up-P1 AAL 1 261 PSZ 1 30 HG 1 - DBA 1 + REF 1 2 DT 1 30 May 2001 RESZ 494 ID|FBpp0003610 SYM|140up-P1 ASAL|FBal0066317==140up+ DT|30 May 2001 |30 May 2001 ARGS|FBgn0010340 DARTS|FBtr0082909 ASGN|FBgn0010340==140up REFDSR { RDID|FBrf0054010 |Sitzler et al. |1991 AAL|261 PSZ|30 | predicted DBA|NA:M62975 |PA:AAD40352 ASTR|FBtr0082909==140up-RA } REFDSR { RDID|FBrf0104946 |FlyBase |1996- ASTR|FBtr0082909==140up-RA } REF { REFM|FBrf0054010 |Sitzler et al. |1991 REFM|FBrf0104946 |FlyBase |1996- } } # EOR PPR { RETE|ID 1 FBpp0082370 SYM 1 140up-PA AAL 1 261 PSZ 1 - HG 1 - DBA 1 - REF 1 1 DT 1 5 Jun 2004 RESZ 285 ID|FBpp0082370 SYM|140up-PA SYN|CG9852-PA ASAL|FBal0066317==140up+ DT|5 Jun 2004 |5 Jun 2004 ASGN|FBgn0010340==140up REFDSR { RDID|FBrf0166453 |FlyBase Genome Annotators |2004 AAL|261 } REF { REFM|FBrf0166453 |FlyBase Genome Annotators |2004 } } # EOR PPR { RETE|ID 1 FBpp0072573 SYM 1 312-PA AAL 1 241 PSZ 1 - HG 1 - DBA 1 - REF 1 1 DT 1 5 Jun 2004 RESZ 319 ID|FBpp0072573 SYM|312-PA SYN|CG9166-PA ASAL|FBal0103396==312+ DT|5 Jun 2004 |5 Jun 2004 ASGN|FBgn0029514==312 REFDSR { RDID|FBrf0166453 |FlyBase Genome Annotators |2004 AAL|241 ASTR|FBtr0072680==312-RA } REF { REFM|FBrf0166453 |FlyBase Genome Annotators |2004 } } # EOR PPR { RETE|ID 1 FBpp0074753 SYM 1 825-Oak-PA AAL 1 154 PSZ 1 - HG 1 - DBA 1 - REF 1 1 DT 1 5 Jun 2004 RESZ 336 ID|FBpp0074753 SYM|825-Oak-PA SYN|CG32208-PA ASAL|FBal0140827==825-Oak+ DT|5 Jun 2004 |5 Jun 2004 ASGN|FBgn0052208==825-Oak REFDSR { RDID|FBrf0166453 |FlyBase Genome Annotators |2004 AAL|154 ASTR|FBtr0074985==825-Oak-RA } REF { REFM|FBrf0166453 |FlyBase Genome Annotators |2004 } } # EOR PPR { RETE|ID 1 FBpp0001575 SYM 1 1731\RTase+P110kD AAL 1 - PSZ 1 110 HG 1 - DBA 1 - REF 1 1 DT 1 30 May 2000 RESZ 734 ID|FBpp0001575 SYM|1731\RTase+P110kD ASAL|FBal0105270==1731\RTase+ DT|30 May 2000 |10 Mar 1998 ASGN|FBgn0012032==1731\RTase REFDSR { RDID|FBrf0056004 |Champion et al. |1992 PSZ|110 ABOD|polyclonal CC|Parts of the FBgn0000007==1731 element were demonstrated to encode peptides displaying | reverse transcriptase activity. Antibodies were prepared against reverse | transcriptase encoding peptides. The antibodies detect a protein of 110kD | which was found in D. melanogaster cells but not cells of D. hydei or D. | virilis. The protein cosediments with virus-like particles displaying | reverse transcriptase activity. } REF { REFM|FBrf0056004 |Champion et al. |1992 } } # EOR PPR { RETE|ID 1 FBpp0071677 SYM 1 a-PA AAL 1 1329 PSZ 1 - HG 1 - DBA 1 - REF 1 1 DT 1 5 Jun 2004 RESZ 312 ID|FBpp0071677 SYM|a-PA SYN|CG6741-PA ASAL|FBal0068527==a+ DT|5 Jun 2004 |5 Jun 2004 ASGN|FBgn0000008==a REFDSR { RDID|FBrf0166453 |FlyBase Genome Annotators |2004 AAL|1329 ASTR|FBtr0071763==a-RA } REF { REFM|FBrf0166453 |FlyBase Genome Annotators |2004 } } # EOR PPR { RETE|ID 1 FBpp0071678 SYM 1 a-PB AAL 1 1329 PSZ 1 - HG 1 - DBA 1 - REF 1 1 DT 1 5 Jun 2004 RESZ 312 ID|FBpp0071678 SYM|a-PB SYN|CG6741-PB ASAL|FBal0068527==a+ DT|5 Jun 2004 |5 Jun 2004 ASGN|FBgn0000008==a REFDSR { RDID|FBrf0166453 |FlyBase Genome Annotators |2004 AAL|1329 ASTR|FBtr0071764==a-RB } REF { REFM|FBrf0166453 |FlyBase Genome Annotators |2004 } } # EOR PPR { RETE|ID 1 FBpp0070234 SYM 1 A3-3-PA AAL 1 613 PSZ 1 - HG 1 - DBA 1 - REF 1 1 DT 1 5 Jun 2004 RESZ 324 ID|FBpp0070234 SYM|A3-3-PA SYN|CG11405-PA ASAL|FBal0101097==A3-3+ DT|5 Jun 2004 |5 Jun 2004 ASGN|FBgn0028550==A3-3 REFDSR { RDID|FBrf0166453 |FlyBase Genome Annotators |2004 AAL|613 ASTR|FBtr0070244==A3-3-RA } REF { REFM|FBrf0166453 |FlyBase Genome Annotators |2004 } } # EOR PPR { RETE|ID 1 FBpp0000011 SYM 1 a5-P1 AAL 1 210 PSZ 1 - HG 1 - DBA 1 + REF 1 3 DT 1 4 Feb 2000 RESZ 514 ID|FBpp0000011 SYM|a5-P1 SYN|a5+P210 ASAL|FBal0068531==a5+ DT|4 Feb 2000 |4 Feb 1998 ARGS|FBgn0011294 DARTS|FBtr0077922 ASGN|FBgn0011294==a5 REFDSR { RDID|FBrf0066935 |Pikielny et al. |1994 AAL|210 DBA|NA:U05243 |PA:AAC46472 ASTR|FBtr0077922==a5-RA } REFDSR { RDID|FBrf0104946 |FlyBase |1996- ASTR|FBtr0077922==a5-RA } REF { REFM|FBrf0066935 |Pikielny et al. |1994 REFM|FBrf0104946 |FlyBase |1996- REFM|FBrf0105495 |FlyBase |1992- } } # EOR PPR { RETE|ID 1 FBpp0077588 SYM 1 a5-PA AAL 1 210 PSZ 1 - HG 1 - DBA 1 - REF 1 1 DT 1 5 Jun 2004 RESZ 276 ID|FBpp0077588 SYM|a5-PA SYN|CG5430-PA ASAL|FBal0068531==a5+ DT|5 Jun 2004 |5 Jun 2004 ASGN|FBgn0011294==a5 REFDSR { RDID|FBrf0166453 |FlyBase Genome Annotators |2004 AAL|210 } REF { REFM|FBrf0166453 |FlyBase Genome Annotators |2004 } } # EOR PPR { RETE|ID 1 FBpp0002947 SYM 1 a6-P1 AAL 1 409 PSZ 1 - HG 1 - DBA 1 - REF 1 1 DT 1 23 Feb 2000 RESZ 304 ID|FBpp0002947 SYM|a6-P1 ASAL|FBal0087232==a6+ DT|23 Feb 2000 |23 Feb 2000 ARGS|FBgn0023130 DARTS|FBtr0070279 ASGN|FBgn0023130==a6 REFDSR { RDID|FBrf0104946 |FlyBase |1996- AAL|409 ASTR|FBtr0070279==a6-RA } REF { REFM|FBrf0104946 |FlyBase |1996- } } # EOR PPR { RETE|ID 1 FBpp0070269 SYM 1 a6-PA AAL 1 409 PSZ 1 - HG 1 - DBA 1 - REF 1 1 DT 1 5 Jun 2004 RESZ 276 ID|FBpp0070269 SYM|a6-PA SYN|CG3771-PA ASAL|FBal0087232==a6+ DT|5 Jun 2004 |5 Jun 2004 ASGN|FBgn0023130==a6 REFDSR { RDID|FBrf0166453 |FlyBase Genome Annotators |2004 AAL|409 } REF { REFM|FBrf0166453 |FlyBase Genome Annotators |2004 } } # EOR PPR { RETE|ID 1 FBpp0075050 SYM 1 a10-PA AAL 1 155 PSZ 1 - HG 1 - DBA 1 - REF 1 1 DT 1 5 Jun 2004 RESZ 319 ID|FBpp0075050 SYM|a10-PA SYN|CG6642-PA ASAL|FBal0071527==a10+ DT|5 Jun 2004 |5 Jun 2004 ASGN|FBgn0011293==a10 REFDSR { RDID|FBrf0166453 |FlyBase Genome Annotators |2004 AAL|155 ASTR|FBtr0075290==a10-RA } REF { REFM|FBrf0166453 |FlyBase Genome Annotators |2004 } } # EOR PPR { RETE|ID 1 FBpp0000010 SYM 1 a10+P155 AAL 1 155 PSZ 1 17.8 HG 1 - DBA 1 + REF 1 3 DT 1 4 Feb 1998 RESZ 568 ID|FBpp0000010 SYM|a10+P155 ASAL|FBal0071527==a10+ DT|4 Feb 1998 |4 Feb 1998 ASGN|FBgn0011293==a10 REFDSR { RDID|FBrf0066935 |Pikielny et al. |1994 AAL|155 DBA|NA:U05244 |PA:AAC46473 ASTR|FBtr0000751==a10+R0.6 } REFDSR { RDID|FBrf0073868 |McKenna et al. |1994 AAL|155 PSZ|17.8 ABOD|polyclonal DBA|NA:U02546 |PA:AAA21358 ASTR|FBtr0000751==a10+R0.6 } REF { REFM|FBrf0066935 |Pikielny et al. |1994 REFM|FBrf0073868 |McKenna et al. |1994 REFM|FBrf0105495 |FlyBase |1992- } } # EOR PPR { RETE|ID 1 FBpp0003350 SYM 1 a+P1329 AAL 1 1329 PSZ 1 143 HG 1 - DBA 1 + REF 1 1 DT 1 21 Nov 2000 RESZ 1724 ID|FBpp0003350 SYM|a+P1329 ASAL|FBal0068527==a+ DT|21 Nov 2000 |21 Nov 2000 ASGN|FBgn0000008==a REFDSR { RDID|FBrf0127206 |Liu and Lengyel |2000 AAL|1329 PSZ|143 | predicted ABOD|polyclonal PCL|FBgn0000008==a protein is found on the apical side of expressing cells and has been | localized to the adherens junction. BODP|FBgn0000008==a protein is expressed dynamically in the embryo in morphogenetically | active epithelia. Zygotic FBgn0000008==a protein is first detected in the posterior | midgut primordium, prior to and during invagination. It is detected in the | Malpighian tubule primordium prior to evagination of the tubule buds and | during evagination and elongation. It is also found in the hindgut, | foregut, salivary gland, and trachea after they have formed and while they | are elongating. In larvae FBgn0000008==a protein is expressed in repeating clusters of | cells along the morphogenetic furrow. ASM|immunolocalization CVBODP|immunolocalization | E | stage >=6 posterior midgut primordium

| E | stage >=10 Malpighian tubule

| E | stage >13 embryonic/larval hindgut

| E embryonic/larval foregut

| E embryonic/larval salivary gland

| L | third instar morphogenetic furrow

PDOM|PDZ domain protein CVCEL|adherens junction DBA|NA:AF188473 |PA:AAF37816 |NA:AF188474 |PA:AAF37817 |NA:AF188475 |PA:AAF37818 ASTR|FBtr0006293==a+RA |FBtr0006294==a+RB |FBtr0006295==a+R5.5 |FBtr0006296==a+R } REF { REFM|FBrf0127206 |Liu and Lengyel |2000 } } # EOR PPR { RETE|ID 1 FBpp0003710 SYM 1 Aac11-P1 AAL 1 536 PSZ 1 - HG 1 - DBA 1 - REF 1 1 DT 1 21 Aug 2001 RESZ 316 ID|FBpp0003710 SYM|Aac11-P1 ASAL|FBal0101915==Aac11+ DT|21 Aug 2001 |21 Aug 2001 ARGS|FBgn0027885 DARTS|FBtr0081001 ASGN|FBgn0027885==Aac11 REFDSR { RDID|FBrf0104946 |FlyBase |1996- AAL|536 ASTR|FBtr0081001==Aac11-RA } REF { REFM|FBrf0104946 |FlyBase |1996- } } # EOR PPR { RETE|ID 1 FBpp0080554 SYM 1 Aac11-PA AAL 1 536 PSZ 1 - HG 1 - DBA 1 - REF 1 1 DT 1 5 Jun 2004 RESZ 285 ID|FBpp0080554 SYM|Aac11-PA SYN|CG6582-PA ASAL|FBal0101915==Aac11+ DT|5 Jun 2004 |5 Jun 2004 ASGN|FBgn0027885==Aac11 REFDSR { RDID|FBrf0166453 |FlyBase Genome Annotators |2004 AAL|536 } REF { REFM|FBrf0166453 |FlyBase Genome Annotators |2004 } } # EOR PPR { RETE|ID 1 FBpp0072163 SYM 1 Aanat1-PA AAL 1 240 PSZ 1 - HG 1 - DBA 1 - REF 1 1 DT 1 5 Jun 2004 RESZ 322 ID|FBpp0072163 SYM|Aanat1-PA SYN|CG3318-PA DT|5 Jun 2004 |5 Jun 2004 ASGN|FBgn0019643==Dat ASAL|FBal0098965==Dat+ REFDSR { RDID|FBrf0166453 |FlyBase Genome Annotators |2004 AAL|240 ASTR|FBtr0072254==Dat-RA } REF { REFM|FBrf0166453 |FlyBase Genome Annotators |2004 } } # EOR PPR { RETE|ID 1 FBpp0089101 SYM 1 Aanat1-PB AAL 1 275 PSZ 1 - HG 1 - DBA 1 - REF 1 1 DT 1 5 Jun 2004 RESZ 322 ID|FBpp0089101 SYM|Aanat1-PB SYN|CG3318-PB DT|5 Jun 2004 |5 Jun 2004 ASGN|FBgn0019643==Dat ASAL|FBal0098965==Dat+ REFDSR { RDID|FBrf0166453 |FlyBase Genome Annotators |2004 AAL|275 ASTR|FBtr0072255==Dat-RB } REF { REFM|FBrf0166453 |FlyBase Genome Annotators |2004 } } # EOR PPR { RETE|ID 1 FBpp0076871 SYM 1 Aats-ala-m-PA AAL 1 1012 PSZ 1 - HG 1 - DBA 1 - REF 1 1 DT 1 5 Jun 2004 RESZ 348 ID|FBpp0076871 SYM|Aats-ala-m-PA SYN|CG4633-PA ASAL|FBal0102309==Aats-ala-m+ DT|5 Jun 2004 |5 Jun 2004 ASGN|FBgn0028962==Aats-ala-m REFDSR { RDID|FBrf0166453 |FlyBase Genome Annotators |2004 AAL|1012 ASTR|FBtr0077168==Aats-ala-m-RA } REF { REFM|FBrf0166453 |FlyBase Genome Annotators |2004 } } # EOR PPR { RETE|ID 1 FBpp0079326 SYM 1 Aats-ala-PA AAL 1 966 PSZ 1 - HG 1 - DBA 1 - REF 1 1 DT 1 5 Jun 2004 RESZ 340 ID|FBpp0079326 SYM|Aats-ala-PA SYN|CG13391-PA ASAL|FBal0097822==Aats-ala+ DT|5 Jun 2004 |5 Jun 2004 ASGN|FBgn0027094==Aats-ala REFDSR { RDID|FBrf0166453 |FlyBase Genome Annotators |2004 AAL|966 ASTR|FBtr0079721==Aats-ala-RA } REF { REFM|FBrf0166453 |FlyBase Genome Annotators |2004 } } # EOR PPR { RETE|ID 1 FBpp0089366 SYM 1 Aats-ala-PB AAL 1 966 PSZ 1 - HG 1 - DBA 1 - REF 1 1 DT 1 5 Jun 2004 RESZ 340 ID|FBpp0089366 SYM|Aats-ala-PB SYN|CG13391-PB ASAL|FBal0097822==Aats-ala+ DT|5 Jun 2004 |5 Jun 2004 ASGN|FBgn0027094==Aats-ala REFDSR { RDID|FBrf0166453 |FlyBase Genome Annotators |2004 AAL|966 ASTR|FBtr0079722==Aats-ala-RB } REF { REFM|FBrf0166453 |FlyBase Genome Annotators |2004 } } # EOR PPR { RETE|ID 1 FBpp0003284 SYM 1 Aats-asp-P1 AAL 1 531 PSZ 1 - HG 1 + DBA 1 + REF 1 2 DT 1 1 Oct 2001 RESZ 548 ID|FBpp0003284 SYM|Aats-asp-P1 SYN|Aats-asp+P531 ASAL|FBal0095935==Aats-asp+ DT|1 Oct 2001 |21 Nov 2000 ARGS|FBgn0002069 DARTS|FBtr0087784 ASGN|FBgn0002069==Aats-asp REFDSR { RDID|FBrf0104946 |FlyBase |1996- ASTR|FBtr0087784==Aats-asp-RA } REFDSR { RDID|FBrf0107310 |Stitzinger et al. |1999 AAL|531 HG|Homo sapiens | AspRS DBA|NA:AF113612 |PA:AAD21582 ASTR|FBtr0087784==Aats-asp-RA } REF { REFM|FBrf0104946 |FlyBase |1996- REFM|FBrf0107310 |Stitzinger et al. |1999 } } # EOR PPR { RETE|ID 1 FBpp0086897 SYM 1 Aats-asp-PA AAL 1 531 PSZ 1 - HG 1 - DBA 1 - REF 1 1 DT 1 5 Jun 2004 RESZ 294 ID|FBpp0086897 SYM|Aats-asp-PA SYN|CG3821-PA ASAL|FBal0095935==Aats-asp+ DT|5 Jun 2004 |5 Jun 2004 ASGN|FBgn0002069==Aats-asp REFDSR { RDID|FBrf0166453 |FlyBase Genome Annotators |2004 AAL|531 } REF { REFM|FBrf0166453 |FlyBase Genome Annotators |2004 } } # EOR PPR { RETE|ID 1 FBpp0084240 SYM 1 Aats-gln-PA AAL 1 778 PSZ 1 - HG 1 - DBA 1 - REF 1 1 DT 1 5 Jun 2004 RESZ 340 ID|FBpp0084240 SYM|Aats-gln-PA SYN|CG10506-PA ASAL|FBal0097818==Aats-gln+ DT|5 Jun 2004 |5 Jun 2004 ASGN|FBgn0027090==Aats-gln REFDSR { RDID|FBrf0166453 |FlyBase Genome Annotators |2004 AAL|778 ASTR|FBtr0084866==Aats-gln-RA } REF { REFM|FBrf0166453 |FlyBase Genome Annotators |2004 } } # EOR PPR { RETE|ID 1 FBpp0083898 SYM 1 Aats-glupro-PA AAL 1 1714 PSZ 1 - HG 1 - DBA 1 - REF 1 1 DT 1 5 Jun 2004 RESZ 352 ID|FBpp0083898 SYM|Aats-glupro-PA SYN|CG5394-PA ASAL|FBal0066329==Aats-glupro+ DT|5 Jun 2004 |5 Jun 2004 ASGN|FBgn0005674==Aats-glupro REFDSR { RDID|FBrf0166453 |FlyBase Genome Annotators |2004 AAL|1714 ASTR|FBtr0084511==Aats-glupro-RA } REF { REFM|FBrf0166453 |FlyBase Genome Annotators |2004 } } # EOR PPR { RETE|ID 1 FBpp0083899 SYM 1 Aats-glupro-PB AAL 1 996 PSZ 1 - HG 1 - DBA 1 - REF 1 1 DT 1 5 Jun 2004 RESZ 351 ID|FBpp0083899 SYM|Aats-glupro-PB SYN|CG5394-PB ASAL|FBal0066329==Aats-glupro+ DT|5 Jun 2004 |5 Jun 2004 ASGN|FBgn0005674==Aats-glupro REFDSR { RDID|FBrf0166453 |FlyBase Genome Annotators |2004 AAL|996 ASTR|FBtr0084512==Aats-glupro-RB } REF { REFM|FBrf0166453 |FlyBase Genome Annotators |2004 } } # EOR PPR { RETE|ID 1 FBpp0000012 SYM 1 Aats-glupro+P1714 AAL 1 1714 PSZ 1 189 HG 1 - DBA 1 + REF 1 2 DT 1 4 Feb 1998 RESZ 809 ID|FBpp0000012 SYM|Aats-glupro+P1714 ASAL|FBal0066329==Aats-glupro+ DT|4 Feb 1998 |4 Feb 1998 ASGN|FBgn0005674==Aats-glupro REFDSR { RDID|FBrf0053898 |Cerini et al. |1991 AAL|1714 PSZ|189 ASTR|FBtr0002285==Aats-glupro+R6.1 CC|A multifunctional enzyme whose amino-terminal domain (domain I) includes a | glutamyl-tRNA synthetase and whose carboxy-terminal domain (domain III) | includes a prolyl-tRNA synthetase. These activities were confirmed by | expression of domains I and III in E. coli and the demonstration of their | ability to aminoacylate tRNA with glutamate and proline. } REFDSR { RDID|FBrf0105495 |FlyBase |1992- DBA|NA:M74104 |PA:AAA28594 } REF { REFM|FBrf0053898 |Cerini et al. |1991 REFM|FBrf0105495 |FlyBase |1992- } } # EOR PPR { RETE|ID 1 FBpp0078150 SYM 1 Aats-ile-PA AAL 1 1229 PSZ 1 - HG 1 - DBA 1 - REF 1 1 DT 1 5 Jun 2004 RESZ 341 ID|FBpp0078150 SYM|Aats-ile-PA SYN|CG11471-PA ASAL|FBal0097814==Aats-ile+ DT|5 Jun 2004 |5 Jun 2004 ASGN|FBgn0027086==Aats-ile REFDSR { RDID|FBrf0166453 |FlyBase Genome Annotators |2004 AAL|1229 ASTR|FBtr0078498==Aats-ile-RA } REF { REFM|FBrf0166453 |FlyBase Genome Annotators |2004 } } # EOR PPR { RETE|ID 1 FBpp0078151 SYM 1 Aats-ile-PC AAL 1 1229 PSZ 1 - HG 1 - DBA 1 - REF 1 1 DT 1 5 Jun 2004 RESZ 341 ID|FBpp0078151 SYM|Aats-ile-PC SYN|CG11471-PC ASAL|FBal0097814==Aats-ile+ DT|5 Jun 2004 |5 Jun 2004 ASGN|FBgn0027086==Aats-ile REFDSR { RDID|FBrf0166453 |FlyBase Genome Annotators |2004 AAL|1229 ASTR|FBtr0078499==Aats-ile-RC } REF { REFM|FBrf0166453 |FlyBase Genome Annotators |2004 } } # EOR PPR { RETE|ID 1 FBpp0078152 SYM 1 Aats-ile-PD AAL 1 1229 PSZ 1 - HG 1 - DBA 1 - REF 1 1 DT 1 5 Jun 2004 RESZ 341 ID|FBpp0078152 SYM|Aats-ile-PD SYN|CG11471-PD ASAL|FBal0097814==Aats-ile+ DT|5 Jun 2004 |5 Jun 2004 ASGN|FBgn0027086==Aats-ile REFDSR { RDID|FBrf0166453 |FlyBase Genome Annotators |2004 AAL|1229 ASTR|FBtr0078500==Aats-ile-RD } REF { REFM|FBrf0166453 |FlyBase Genome Annotators |2004 } } # EOR PPR { RETE|ID 1 FBpp0003725 SYM 1 Aats-phe-P1 AAL 1 453 PSZ 1 - HG 1 - DBA 1 - REF 1 1 DT 1 1 Oct 2001 RESZ 326 ID|FBpp0003725 SYM|Aats-phe-P1 ASAL|FBal0079719==Aats-phe+ DT|1 Oct 2001 |1 Oct 2001 ARGS|FBgn0020766 DARTS|FBtr0087594 ASGN|FBgn0020766==Aats-phe REFDSR { RDID|FBrf0104946 |FlyBase |1996- AAL|453 ASTR|FBtr0087594==Aats-phe-RA } REF { REFM|FBrf0104946 |FlyBase |1996- } } # EOR PPR { RETE|ID 1 FBpp0086720 SYM 1 Aats-phe-PA AAL 1 453 PSZ 1 - HG 1 - DBA 1 - REF 1 1 DT 1 5 Jun 2004 RESZ 295 ID|FBpp0086720 SYM|Aats-phe-PA SYN|CG13348-PA ASAL|FBal0079719==Aats-phe+ DT|5 Jun 2004 |5 Jun 2004 ASGN|FBgn0020766==Aats-phe REFDSR { RDID|FBrf0166453 |FlyBase Genome Annotators |2004 AAL|453 } REF { REFM|FBrf0166453 |FlyBase Genome Annotators |2004 } } # EOR PPR { RETE|ID 1 FBpp0082542 SYM 1 Aats-ser-PA AAL 1 417 PSZ 1 - HG 1 - DBA 1 - REF 1 1 DT 1 5 Jun 2004 RESZ 339 ID|FBpp0082542 SYM|Aats-ser-PA SYN|CG4938-PA ASAL|FBal0080602==Aats-ser+ DT|5 Jun 2004 |5 Jun 2004 ASGN|FBgn0021750==Aats-ser REFDSR { RDID|FBrf0166453 |FlyBase Genome Annotators |2004 AAL|417 ASTR|FBtr0083086==Aats-ser-RA } REF { REFM|FBrf0166453 |FlyBase Genome Annotators |2004 } } # EOR PPR { RETE|ID 1 FBpp0002505 SYM 1 Aats-ser+PA AAL 1 322 PSZ 1 - HG 1 - DBA 1 + REF 1 1 DT 1 16 Sep 1998 RESZ 298 ID|FBpp0002505 SYM|Aats-ser+PA ASAL|FBal0080602==Aats-ser+ DT|16 Sep 1998 |16 Sep 1998 ASGN|FBgn0021750==Aats-ser REFDSR { RDID|FBrf0090406 |Armes and Fried |1996 AAL|322 DBA|NA:Y14823 |PA:CAA75101 } REF { REFM|FBrf0090406 |Armes and Fried |1996 } } # EOR PPR { RETE|ID 1 FBpp0079914 SYM 1 Aats-thr-PA AAL 1 747 PSZ 1 - HG 1 - DBA 1 - REF 1 1 DT 1 5 Jun 2004 RESZ 339 ID|FBpp0079914 SYM|Aats-thr-PA SYN|CG5353-PA ASAL|FBal0097809==Aats-thr+ DT|5 Jun 2004 |5 Jun 2004 ASGN|FBgn0027081==Aats-thr REFDSR { RDID|FBrf0166453 |FlyBase Genome Annotators |2004 AAL|747 ASTR|FBtr0080332==Aats-thr-RA } REF { REFM|FBrf0166453 |FlyBase Genome Annotators |2004 } } # EOR PPR { RETE|ID 1 FBpp0079913 SYM 1 Aats-thr-PB AAL 1 690 PSZ 1 - HG 1 - DBA 1 - REF 1 1 DT 1 5 Jun 2004 RESZ 339 ID|FBpp0079913 SYM|Aats-thr-PB SYN|CG5353-PB ASAL|FBal0097809==Aats-thr+ DT|5 Jun 2004 |5 Jun 2004 ASGN|FBgn0027081==Aats-thr REFDSR { RDID|FBrf0166453 |FlyBase Genome Annotators |2004 AAL|690 ASTR|FBtr0080331==Aats-thr-RB } REF { REFM|FBrf0166453 |FlyBase Genome Annotators |2004 } } # EOR PPR { RETE|ID 1 FBpp0079915 SYM 1 Aats-thr-PC AAL 1 690 PSZ 1 - HG 1 - DBA 1 - REF 1 1 DT 1 5 Jun 2004 RESZ 339 ID|FBpp0079915 SYM|Aats-thr-PC SYN|CG5353-PC ASAL|FBal0097809==Aats-thr+ DT|5 Jun 2004 |5 Jun 2004 ASGN|FBgn0027081==Aats-thr REFDSR { RDID|FBrf0166453 |FlyBase Genome Annotators |2004 AAL|690 ASTR|FBtr0080333==Aats-thr-RC } REF { REFM|FBrf0166453 |FlyBase Genome Annotators |2004 } } # EOR PPR { RETE|ID 1 FBpp0081460 SYM 1 Aats-trp-PA AAL 1 430 PSZ 1 - HG 1 - DBA 1 - REF 1 1 DT 1 5 Jun 2004 RESZ 339 ID|FBpp0081460 SYM|Aats-trp-PA SYN|CG9735-PA ASAL|FBal0073277==Aats-trp+ DT|5 Jun 2004 |5 Jun 2004 ASGN|FBgn0010803==Aats-trp REFDSR { RDID|FBrf0166453 |FlyBase Genome Annotators |2004 AAL|430 ASTR|FBtr0081980==Aats-trp-RA } REF { REFM|FBrf0166453 |FlyBase Genome Annotators |2004 } } # EOR PPR { RETE|ID 1 FBpp0081461 SYM 1 Aats-trp-PB AAL 1 430 PSZ 1 - HG 1 - DBA 1 - REF 1 1 DT 1 5 Jun 2004 RESZ 339 ID|FBpp0081461 SYM|Aats-trp-PB SYN|CG9735-PB ASAL|FBal0073277==Aats-trp+ DT|5 Jun 2004 |5 Jun 2004 ASGN|FBgn0010803==Aats-trp REFDSR { RDID|FBrf0166453 |FlyBase Genome Annotators |2004 AAL|430 ASTR|FBtr0081981==Aats-trp-RB } REF { REFM|FBrf0166453 |FlyBase Genome Annotators |2004 } } # EOR PPR { RETE|ID 1 FBpp0003293 SYM 1 Aats-trp+P430 AAL 1 430 PSZ 1 51 HG 1 - DBA 1 + REF 1 1 DT 1 21 Nov 2000 RESZ 940 ID|FBpp0003293 SYM|Aats-trp+P430 ASAL|FBal0073277==Aats-trp+ DT|21 Nov 2000 |21 Nov 2000 ASGN|FBgn0010803==Aats-trp REFDSR { RDID|FBrf0108275 |Seshaiah and Andrew |1999 AAL|430 PSZ|51 | predicted BODP|FBgn0010803==Aats-trp protein is found in the salivary gland and its primordia. In | addition to the salivary gland staining, the protein is found at fairly | high levels all over the embryo. ASM|immunolocalization CVBODP|immunolocalization | E embyonic/larval salivary gland

| E

ubiquitous DBA|NA:AF125156 |PA:AAF20166 |NA:AF125157 |PA:AAF20167 ASTR|FBtr0006211==Aats-trp+R2.6 |FBtr0006212==Aats-trp+RB CC|Bacterially expressed and purified FBgn0010803==Aats-trp protein was shown to have | tRNAtrp aminoacylation activity. } REF { REFM|FBrf0108275 |Seshaiah and Andrew |1999 } } # EOR PPR { RETE|ID 1 FBpp0086848 SYM 1 Aats-val-PA AAL 1 1049 PSZ 1 - HG 1 - DBA 1 - REF 1 1 DT 1 5 Jun 2004 RESZ 340 ID|FBpp0086848 SYM|Aats-val-PA SYN|CG4062-PA ASAL|FBal0097807==Aats-val+ DT|5 Jun 2004 |5 Jun 2004 ASGN|FBgn0027079==Aats-val REFDSR { RDID|FBrf0166453 |FlyBase Genome Annotators |2004 AAL|1049 ASTR|FBtr0087735==Aats-val-RA } REF { REFM|FBrf0166453 |FlyBase Genome Annotators |2004 } } # EOR PPR { RETE|ID 1 FBpp0086847 SYM 1 Aats-val-PB AAL 1 1049 PSZ 1 - HG 1 - DBA 1 - REF 1 1 DT 1 5 Jun 2004 RESZ 340 ID|FBpp0086847 SYM|Aats-val-PB SYN|CG4062-PB ASAL|FBal0097807==Aats-val+ DT|5 Jun 2004 |5 Jun 2004 ASGN|FBgn0027079==Aats-val REFDSR { RDID|FBrf0166453 |FlyBase Genome Annotators |2004 AAL|1049 ASTR|FBtr0087734==Aats-val-RB } REF { REFM|FBrf0166453 |FlyBase Genome Annotators |2004 } } # EOR PPR { RETE|ID 1 FBpp0076185 SYM 1 aay-PA AAL 1 270 PSZ 1 - HG 1 - DBA 1 - REF 1 1 DT 1 5 Jun 2004 RESZ 319 ID|FBpp0076185 SYM|aay-PA SYN|CG3705-PA ASAL|FBal0087231==aay+ DT|5 Jun 2004 |5 Jun 2004 ASGN|FBgn0023129==aay REFDSR { RDID|FBrf0166453 |FlyBase Genome Annotators |2004 AAL|270 ASTR|FBtr0076457==aay-RA } REF { REFM|FBrf0166453 |FlyBase Genome Annotators |2004 } } # EOR PPR { RETE|ID 1 FBpp0000013 SYM 1 ab-P1 AAL 1 904 PSZ 1 - HG 1 - DBA 1 + REF 1 3 DT 1 4 Feb 2000 RESZ 563 ID|FBpp0000013 SYM|ab-P1 SYN|ab+P904 ASAL|FBal0068533==ab+ DT|4 Feb 2000 |4 Feb 1998 ARGS|FBgn0000011 DARTS|FBtr0080204 ASGN|FBgn0000011==ab REFDSR { RDID|FBrf0085244 |Hu et al. |1995 AAL|904 ABOD|polyclonal ASTR|FBtr0080204==ab-RA } REFDSR { RDID|FBrf0104946 |FlyBase |1996- ASTR|FBtr0080204==ab-RA } REFDSR { RDID|FBrf0105495 |FlyBase |1992- DBA|NA:U43733 |PA:AAA86639 } REF { REFM|FBrf0085244 |Hu et al. |1995 REFM|FBrf0104946 |FlyBase |1996- REFM|FBrf0105495 |FlyBase |1992- } } # EOR PPR { RETE|ID 1 FBpp0001817 SYM 1 ab-P2 AAL 1 894 PSZ 1 - HG 1 - DBA 1 - REF 1 2 DT 1 4 Feb 2000 RESZ 459 ID|FBpp0001817 SYM|ab-P2 SYN|ab+P894 ASAL|FBal0068533==ab+ DT|4 Feb 2000 |10 Mar 1998 ARGS|FBgn0000011 DARTS|FBtr0080203 ASGN|FBgn0000011==ab REFDSR { RDID|FBrf0085244 |Hu et al. |1995 AAL|894 ABOD|polyclonal ASTR|FBtr0080203==ab-RB } REFDSR { RDID|FBrf0104946 |FlyBase |1996- ASTR|FBtr0080203==ab-RB } REF { REFM|FBrf0085244 |Hu et al. |1995 REFM|FBrf0104946 |FlyBase |1996- } } # EOR PPR { RETE|ID 1 FBpp0079793 SYM 1 ab-PA AAL 1 904 PSZ 1 - HG 1 - DBA 1 - REF 1 1 DT 1 5 Jun 2004 RESZ 276 ID|FBpp0079793 SYM|ab-PA SYN|CG4807-PA ASAL|FBal0068533==ab+ DT|5 Jun 2004 |5 Jun 2004 ASGN|FBgn0000011==ab REFDSR { RDID|FBrf0166453 |FlyBase Genome Annotators |2004 AAL|904 } REF { REFM|FBrf0166453 |FlyBase Genome Annotators |2004 } } # EOR PPR { RETE|ID 1 FBpp0079792 SYM 1 ab-PB AAL 1 894 PSZ 1 - HG 1 - DBA 1 - REF 1 1 DT 1 5 Jun 2004 RESZ 276 ID|FBpp0079792 SYM|ab-PB SYN|CG4807-PB ASAL|FBal0068533==ab+ DT|5 Jun 2004 |5 Jun 2004 ASGN|FBgn0000011==ab REFDSR { RDID|FBrf0166453 |FlyBase Genome Annotators |2004 AAL|894 } REF { REFM|FBrf0166453 |FlyBase Genome Annotators |2004 } } # EOR PPR { RETE|ID 1 FBpp0001816 SYM 1 ab+P AAL 1 - PSZ 1 - HG 1 - DBA 1 + REF 1 1 DT 1 20 Mar 1998 RESZ 1200 ID|FBpp0001816 SYM|ab+P ASAL|FBal0068533==ab+ DT|20 Mar 1998 |10 Mar 1998 ASGN|FBgn0000011==ab REFDSR { RDID|FBrf0085244 |Hu et al. |1995 BODP|FBgn0000011==ab is expressed in all the cells of the ventral midline starting in stage | 9. The only other site of nervous system expression is the stomatogastric | nervous system and its precursors. Epidermal expression begins in stage 11 | in a pattern of stripes and is uniform by stage 12. FBgn0000011==ab is expressed in | all 30 embryonic abdominal muscles with the highest concentrations in the | ventral longitudinal, ventral oblique, and segmental border muscles. FBgn0000011==ab | is also expressed in all imaginal discs. ASM|immunolocalization CVBODP| E | stage >=9 ventral midline

| E embryonic stomatogastric nervous system

| E VUM precursor

| E | stage >=11 epidermis

| E | stage >=14 larval muscle system

| L eye-antennal disc

| L dorsal mesothoracic disc

| L imaginal disc

CVCEL|nucleus DBA|NA:U43733 |PA:AAA86639 } REF { REFM|FBrf0085244 |Hu et al. |1995 } } # EOR PPR { RETE|ID 1 FBpp0000014 SYM 1 abd-A-P1 AAL 1 330 PSZ 1 - HG 1 - DBA 1 + REF 1 13 DT 1 4 Feb 2000 RESZ 7921 ID|FBpp0000014 SYM|abd-A-P1 SYN|abd-A+P330 ASAL|FBal0068535==abd-A+ DT|4 Feb 2000 |4 Feb 1998 ARGS|FBgn0000014 DARTS|FBtr0083387 ASGN|FBgn0000014==abd-A REFDSR { RDID|FBrf0049619 |Tremml and Bienz |1989 BODP|FBgn0000014==abd-A protein is first detected at the germ band retraction stage in the | visceral mesoderm of the midgut and in the ectoderm of parasegments 8-12. ASM|immunolocalization CVBODP| E | stage 13-14 visceral mesoderm embryonic/larval midgut } REFDSR { RDID|FBrf0051550 |Macias et al. |1990 ABOD|polyclonal AGT|FBal0000112==Abd-BM1 |FBal0033317==Abd-BM5 |FBal0000144==Abd-Biab9-x23-1 |FBal0000142==Abd-Biab9-tuh-3 BODP|The anterior limit of FBgn0000014==abd-A protein is strictly parasegmental at | parasegment 7. The posterior limit is less well defined. The expression is | modulated within metameres with the strongest expression in the posterior | compartments. In the anterior compartments there is a gradient which | diminishes towards the posterior. FBgn0000014==abd-A protein is also present in the | mesoderm but is out of register by one parasegment with respect to ectoderm | expression and extends from parasegment 8-12. FBgn0000014==abd-A expression is | observed in the ectoderm, the tracheal tree, the ventral nerve cord, the | visceral mesoderm and the amnioserosa. Embryos homozygous for Df(3R)109 | or FBab0002632==Df(3R)P9 have no FBgn0000014==abd-A antigen. Ectopic expression of FBgn0000014==abd-A | protein is observed in parasegments 13-15 (or subsets thereof) in several | FBgn0000015==Abd-B mutants. ASM|immunolocalization CVBODP| E parasegment 7..13 ectoderm

| E parasegment 8..12 mesoderm

| E tracheal pit

| E embryonic/larval trachea

| E ventral nerve cord

| E parasegment 8..12 visceral mesoderm

| E amnioserosa

CVCEL|nucleus } REFDSR { RDID|FBrf0051832 |Karch et al. |1990 AAL|330 ABOD|polyclonal BODP|FBgn0000014==abd-A protein is first detected in 4 hour embryos and persists through | embryonic and early larval development. FBgn0000014==abd-A protein is expressed in | parasegments 7-13 (PS7-13) which correspond to abdominal segements 2-7 | (A2-7). Expression of FBgn0000014==abd-A is complementary to that of FBgn0003944==Ubx and | highest levels are in the anterior of each parasegment. Throughout | development FBgn0000014==abd-A is localized to the nuclei of expressing cells. At the | beginning of germ band retraction, FBgn0000014==abd-A protein is detected in the | mesoderm flanking the embryonic gut, surrounding the spiricle pits, the | neuroblasts near the embryonic midline and in the developing tracheal | tubes. Later in development expression is detected along the ventral nerve | cord, and staining is more pronounced toward the posterior of the embryo. | High levels of FBgn0000014==abd-A are detected along the anterior furrow of the gut | sac and along the visceral mesoderm of the gut. Following dorsal closure, | FBgn0000014==abd-A protein is detected in the pericardial cells and the lateral muscle | fibers around the heart, as well as in the gonadal precursor and | chordotonal organs. ASM|immunolocalization CVBODP|immunolocalization | E | stage 9-17 anterior | segmentally repeated

parasegment 7-13 | E | stage 12 embryonic/larval spiracle

| E | stage 12 mesoderm embryonic gut

| E | stage 12 neuroblast

| E | stage 12 visceral mesoderm

| E | stage 13-14 epidermis

| E | stage 13-14 embryonic/larval trachea

| E | stage 13-14 ventral nerve cord

segment A2-A7 | E | stage 15 pericardial cell

| E | stage 15 lateral | muscle fibre

| E | stage 16 gonad

| E | stage 16 ISN

| E | stage 16 chordotonal organ

PDOM|'Homeobox' domain signature CVCEL|nucleus DBA|NA:X54453 |PA:CAA38321 ASTR|FBtr0005404==abd-A+R5.1 |FBtr0083387==abd-A-RA } REFDSR { RDID|FBrf0051840 |Kellerman et al. |1990 ASM|immunolocalization CVBODP|immunolocalization | E | stage 7-12 parasegment 7-12

} REFDSR { RDID|FBrf0053795 |Sanchez-Herrero |1991 AGT|Abd-Biab9-Uab1/TM6B |FBal0027952==Abd-Biab8-rv96 |FBal0000142==Abd-Biab9-tuh-3 BODP|Df(3R)P-10 which removes the iab2 regulatory region and part of the FBgn0000014==abd-A | transcription unit causes a gradient of expression of FBgn0000014==abd-A protein in | the epidermis and a less evident gradient in the nerve cord. Staining is | barely detectable in parasegment 7 and increases gradually posteriorly. In | Abd-B[iab9-Uab1] mutant embryos, there is a general reduction in FBgn0000014==abd-A | levels and ectopic FBgn0000014==abd-A expression in the first abdominal segment and in | parasegments 14 and 15. In embryo homozygous for Abd-B[iab9-Uab1], | FBal0027952==Abd-B[iab8-rv96] and sometimes Abd-B[iab9-tuh-3], nuclei posterior to | parasegment 13 stain for FBgn0000014==abd-A. The ectopic expression is in the | posterior region of abdominal segment 8 and in some cells of the posterior | region of abdominal segment 9. ASM|immunolocalization } REFDSR { RDID|FBrf0055868 |Cumberledge et al. |1992 ASM|immunolocalization CVBODP|immunolocalization | E | stage 13 epidermis gonad

| E | stage 13 epidermis ventral intersegmantal neuron

| E | stage 13 abdominal 4-7 vental intersegmental neuron

| E | stage 13 ventral nerve cells

| E |stage 13

parasegment 7-13 } REFDSR { RDID|FBrf0063844 |Rowe and Akam |1988 BODP|FBgn0000014==abd-A protein is expressed in parasegments 7 through 13 in a segmentally | repeated pattern. A gradient of the antigen is observed, with higher | levels at the anterior border of the parasegments and lower levels toward | the posterior. This gradient is not detected by in situ hybridization, and | therefore, may be post-translationally regulated. Prominant expression is | detected in the ventral nervous system. ASM|immunolocalization CVBODP| E | stage 8 parasegment 7-13

| E | stage 12 ventral nervous system parasegment 7-13

ASTR|FBtr0005404==abd-A+R5.1 |FBtr0083387==abd-A-RA } REFDSR { RDID|FBrf0074351 |Sanchez-Herrero et al. |1994 ASM|immunolocalization CVBODP| E | stage 12 parasegment 7-13

} REFDSR { RDID|FBrf0074435 |Shimell et al. |1994 CVBODP| E | stage 10 parasegment 7-13

segmentally repeated } REFDSR { RDID|FBrf0089610 |Casares et al. |1996 ASM|immunolocalization CVBODP| L dorsal mesothoracic disc | retricted

} REFDSR { RDID|FBrf0104946 |FlyBase |1996- ASTR|FBtr0083387==abd-A-RA } REFDSR { RDID|FBrf0105495 |FlyBase |1992- DBA|NA:U31961 |PA:AAA84406 |NA:X54453 |PA:CAA38321 } REF { REFM|FBrf0000000Flybase Curation REFM|FBrf0049619 |Tremml and Bienz |1989 REFM|FBrf0051550 |Macias et al. |1990 REFM|FBrf0051832 |Karch et al. |1990 REFM|FBrf0051840 |Kellerman et al. |1990 REFM|FBrf0053795 |Sanchez-Herrero |1991 REFM|FBrf0055868 |Cumberledge et al. |1992 REFM|FBrf0063844 |Rowe and Akam |1988 REFM|FBrf0074351 |Sanchez-Herrero et al. |1994 REFM|FBrf0074435 |Shimell et al. |1994 REFM|FBrf0089610 |Casares et al. |1996 REFM|FBrf0104946 |FlyBase |1996- REFM|FBrf0105495 |FlyBase |1992- } } # EOR PPR { RETE|ID 1 FBpp0082828 SYM 1 abd-A-PA AAL 1 330 PSZ 1 - HG 1 - DBA 1 - REF 1 1 DT 1 5 Jun 2004 RESZ 286 ID|FBpp0082828 SYM|abd-A-PA SYN|CG10325-PA ASAL|FBal0068535==abd-A+ DT|5 Jun 2004 |5 Jun 2004 ASGN|FBgn0000014==abd-A REFDSR { RDID|FBrf0166453 |FlyBase Genome Annotators |2004 AAL|330 } REF { REFM|FBrf0166453 |FlyBase Genome Annotators |2004 } } # EOR PPR { RETE|ID 1 FBpp0082829 SYM 1 abd-A-PB AAL 1 590 PSZ 1 - HG 1 - DBA 1 - REF 1 1 DT 1 5 Jun 2004 RESZ 328 ID|FBpp0082829 SYM|abd-A-PB SYN|CG10325-PB ASAL|FBal0068535==abd-A+ DT|5 Jun 2004 |5 Jun 2004 ASGN|FBgn0000014==abd-A REFDSR { RDID|FBrf0166453 |FlyBase Genome Annotators |2004 AAL|590 ASTR|FBtr0083388==abd-A-RB } REF { REFM|FBrf0166453 |FlyBase Genome Annotators |2004 } } # EOR PPR { RETE|ID 1 FBpp0002687 SYM 1 abd-A+P AAL 1 - PSZ 1 - HG 1 - DBA 1 - REF 1 1 DT 1 5 Jan 2000 RESZ 429 ID|FBpp0002687 SYM|abd-A+P ASAL|FBal0068535==abd-A+ DT|5 Jan 2000 |13 Sep 1999 ASGN|FBgn0000014==abd-A REFDSR { RDID|FBrf0088118 |Freeland and Kuhn |1996 ASM|immunolocalization CVBODP|immunolocalization | L | third instar female genital disc | restricted

| L | third instar male genital disc | restricted

} REF { REFM|FBrf0088118 |Freeland and Kuhn |1996 } } # EOR PPR { RETE|ID 1 FBpp0000015 SYM 1 abd-A+P590 AAL 1 - PSZ 1 - HG 1 - DBA 1 + REF 1 1 DT 1 4 Feb 1998 RESZ 267 ID|FBpp0000015 SYM|abd-A+P590 ASAL|FBal0068535==abd-A+ DT|4 Feb 1998 |4 Feb 1998 ASGN|FBgn0000014==abd-A REFDSR { RDID|FBrf0105495 |FlyBase |1992- DBA|NA:U31961 |PA:AAA84405 } REF { REFM|FBrf0105495 |FlyBase |1992- } } # EOR PPR { RETE|ID 1 FBpp0082824 SYM 1 Abd-B-PA AAL 1 270 PSZ 1 - HG 1 - DBA 1 - REF 1 1 DT 1 5 Jun 2004 RESZ 328 ID|FBpp0082824 SYM|Abd-B-PA SYN|CG11648-PA ASAL|FBal0066331==Abd-B+ DT|5 Jun 2004 |5 Jun 2004 ASGN|FBgn0000015==Abd-B REFDSR { RDID|FBrf0166453 |FlyBase Genome Annotators |2004 AAL|270 ASTR|FBtr0083382==Abd-B-RA } REF { REFM|FBrf0166453 |FlyBase Genome Annotators |2004 } } # EOR PPR { RETE|ID 1 FBpp0082826 SYM 1 Abd-B-PB AAL 1 493 PSZ 1 - HG 1 - DBA 1 - REF 1 1 DT 1 5 Jun 2004 RESZ 328 ID|FBpp0082826 SYM|Abd-B-PB SYN|CG11648-PB ASAL|FBal0066331==Abd-B+ DT|5 Jun 2004 |5 Jun 2004 ASGN|FBgn0000015==Abd-B REFDSR { RDID|FBrf0166453 |FlyBase Genome Annotators |2004 AAL|493 ASTR|FBtr0083384==Abd-B-RB } REF { REFM|FBrf0166453 |FlyBase Genome Annotators |2004 } } # EOR PPR { RETE|ID 1 FBpp0082823 SYM 1 Abd-B-PC AAL 1 270 PSZ 1 - HG 1 - DBA 1 - REF 1 1 DT 1 5 Jun 2004 RESZ 328 ID|FBpp0082823 SYM|Abd-B-PC SYN|CG11648-PC ASAL|FBal0066331==Abd-B+ DT|5 Jun 2004 |5 Jun 2004 ASGN|FBgn0000015==Abd-B REFDSR { RDID|FBrf0166453 |FlyBase Genome Annotators |2004 AAL|270 ASTR|FBtr0083381==Abd-B-RC } REF { REFM|FBrf0166453 |FlyBase Genome Annotators |2004 } } # EOR PPR { RETE|ID 1 FBpp0082825 SYM 1 Abd-B-PD AAL 1 270 PSZ 1 - HG 1 - DBA 1 - REF 1 1 DT 1 5 Jun 2004 RESZ 328 ID|FBpp0082825 SYM|Abd-B-PD SYN|CG11648-PD ASAL|FBal0066331==Abd-B+ DT|5 Jun 2004 |5 Jun 2004 ASGN|FBgn0000015==Abd-B REFDSR { RDID|FBrf0166453 |FlyBase Genome Annotators |2004 AAL|270 ASTR|FBtr0083383==Abd-B-RD } REF { REFM|FBrf0166453 |FlyBase Genome Annotators |2004 } } # EOR PPR { RETE|ID 1 FBpp0089276 SYM 1 Abd-B-PE AAL 1 270 PSZ 1 - HG 1 - DBA 1 - REF 1 1 DT 1 5 Jun 2004 RESZ 328 ID|FBpp0089276 SYM|Abd-B-PE SYN|CG11648-PE ASAL|FBal0066331==Abd-B+ DT|5 Jun 2004 |5 Jun 2004 ASGN|FBgn0000015==Abd-B REFDSR { RDID|FBrf0166453 |FlyBase Genome Annotators |2004 AAL|270 ASTR|FBtr0083385==Abd-B-RE } REF { REFM|FBrf0166453 |FlyBase Genome Annotators |2004 } } # EOR PPR { RETE|ID 1 FBpp0002232 SYM 1 Abd-B+P AAL 1 - PSZ 1 - HG 1 - DBA 1 - REF 1 6 DT 1 5 Jan 2000 RESZ 2421 ID|FBpp0002232 SYM|Abd-B+P ASAL|FBal0066331==Abd-B+ DT|5 Jan 2000 |10 Mar 1998 ASGN|FBgn0000015==Abd-B REFDSR { RDID|FBrf0049619 |Tremml and Bienz |1989 BODP|FBgn0000015==Abd-B protein is first detected at germ band retraction stage in the | midgut and hindgut visceral mesoderm and the ectoderm of parasegments 11-15. ASM|immunolocalization CVBODP| E | stage 13-14 visceral mesoderm embryonic/larval midgut | E | stage 13-14 visceral mesoderm embryonic/larval hindgut } REFDSR { RDID|FBrf0051569 |de Lorenzi and Bienz |1990 ABOD|polyclonal BODP|The FBgn0000015==Abd-B protein is first detected in stage 10 embryos in the anterior | region of parasegment 15, parasegment 14 and the posterior region of | parasegment 13. By stage 11, the anterior boundary of FBgn0000015==Abd-B expression is | expanded into parasegment 11, and expression is detected mainly in the | visceral mesoderm of parasegments 11-13. By stage 13 of embryogenesis, the | anterior boarder of expression is extended into parasegment 10 of the ectoderm. ASM|immunolocalization CVBODP| E | stage 10 parasegment 13-15

| E | stage 11-13 parasegment 11-15

| E | stage 11 visceral mesoderm parasegment 11-14

| E | stage 13 ectoderm parasegment 10-13

CVCEL|nucleus CC|The antibody reported in this paper recognizes both the Abd-B-m and Abd-B-r proteins. } REFDSR { RDID|FBrf0068620 |Orlando and Paro |1993 BODP|FBgn0000015==Abd-B protein is expressed in SL-2 cells. ASM|western blot |immunolocalization } REFDSR { RDID|FBrf0072541 |Bachiller et al. |1994 ASM|immunolocalization CVBODP| E | stage 12 parasegment 11-14

} REFDSR { RDID|FBrf0080088 |Hendrickson and Sakonju |1995 ASM|immunolocalization CVBODP| E | stage 12 parasegment 10-14

} REFDSR { RDID|FBrf0088118 |Freeland and Kuhn |1996 ASM|immunolocalization CVBODP|immunolocalization | L | third instar female genital disc | restricted

| L | third instar male genital disc | restricted

} REF { REFM|FBrf0049619 |Tremml and Bienz |1989 REFM|FBrf0051569 |de Lorenzi and Bienz |1990 REFM|FBrf0068620 |Orlando and Paro |1993 REFM|FBrf0072541 |Bachiller et al. |1994 REFM|FBrf0080088 |Hendrickson and Sakonju |1995 REFM|FBrf0088118 |Freeland and Kuhn |1996 } } # EOR PPR { RETE|ID 1 FBpp0000017 SYM 1 Abd-B+P270 AAL 1 270 PSZ 1 30 HG 1 - DBA 1 + REF 1 4 DT 1 4 Feb 1998 RESZ 3032 ID|FBpp0000017 SYM|Abd-B+P270 SYN|r ASAL|FBal0066331==Abd-B+ DT|4 Feb 1998 |4 Feb 1998 ASGN|FBgn0000015==Abd-B REFDSR { RDID|FBrf0049804 |Celniker et al. |1989 PSZ|36 ABOD|monoclonal AGT|FBal0013553==Pc3 PCL|FBgn0000015==Abd-B protein is detected in embryonic nuclear extracts. BODP|FBgn0000015==Abd-B protein is expressed in the embryo starting in stage 8. It is | detected in the ectoderm and mesoderm of parasegments 13-15 and in the | mesoderm of parasegments 11 and 12. It is strongly expressed in the CNS at | germband retraction. CNS staining is strongest in parasegment 14 and | diminishes in parasegments 12 and 13. It is also expressed in Malpighian | tubules, in visceral mesoderm, in cells surrounding the posterior | spiracles, and in the proctodeal primordium. In FBgn0003042==Pc embryos, FBgn0000015==Abd-B | protein can be detected in the ectoderm and neuromeres of all segments. ASM|immunolocalization CVBODP| E | mid-late parasegment 13..15 ectoderm

| E | mid-late parasegment 11..15 mesoderm

| E | mid-late parasegment 12..14 embryonic central nervous system | presumptive

| E | mid-late visceral mesoderm

| E | mid-late Malpighian tubule

| E | mid-late spiracle

| E | mid-late proctodeum

CVCEL|nucleus ASTR|FBtr0002268==Abd-B+R3.3 |FBtr0002269==Abd-B+R3.7 |FBtr0002270==Abd-B+R8.0 CC|The expression pattern is a composite pattern for the ABD-BI and ABD-BII proteins. } REFDSR { RDID|FBrf0053790 |Boulet et al. |1991 PSZ|30 ABOD|polyclonal BODP|The 272aa FBgn0000015==Abd-B protein is present in parasegment 14. Mutants affecting | "r" function have greatly reduced levels of protein in parasegment 14. ASM|immunolocalization CVBODP| E | stage >=12 parasegment 14

ASTR|FBtr0002268==Abd-B+R3.3 |FBtr0002269==Abd-B+R3.7 |FBtr0002270==Abd-B+R8.0 CC|Antibodies that recognize both the 272aa and 493aa FBgn0000015==Abd-B proteins were made. } REFDSR { RDID|FBrf0054623 |Ali and Bienz |1991 AAL|270 CC|The ABD-BI protein corresponds to ABD-BII with a large N-terminal extension; | the two proteins contain the same homeodomain. There are two strong | transcriptional activation domains in the common part of the two proteins. | The ABD-BI-specific exon contains additional transcriptional activation | potential, although it is a weaker transcriptional activator than the | ABD-BII, apparently due to inhibitory sequences in the ABD-BI-specific exon. } REFDSR { RDID|FBrf0105495 |FlyBase |1992- DBA|NA:U31961 |PA:AAA84403 |NA:X15080 |PA:CAA33187 } REF { REFM|FBrf0049804 |Celniker et al. |1989 REFM|FBrf0053790 |Boulet et al. |1991 REFM|FBrf0054623 |Ali and Bienz |1991 REFM|FBrf0105495 |FlyBase |1992- } } # EOR PPR { RETE|ID 1 FBpp0000018 SYM 1 Abd-B+P491 AAL 1 - PSZ 1 - HG 1 - DBA 1 + REF 1 1 DT 1 4 Feb 1998 RESZ 267 ID|FBpp0000018 SYM|Abd-B+P491 ASAL|FBal0066331==Abd-B+ DT|4 Feb 1998 |4 Feb 1998 ASGN|FBgn0000015==Abd-B REFDSR { RDID|FBrf0105495 |FlyBase |1992- DBA|NA:X16134 |PA:CAA34260 } REF { REFM|FBrf0105495 |FlyBase |1992- } } # EOR PPR { RETE|ID 1 FBpp0000019 SYM 1 Abd-B+P493 AAL 1 491 PSZ 1 55 HG 1 - DBA 1 + REF 1 4 DT 1 4 Feb 1998 RESZ 3215 ID|FBpp0000019 SYM|Abd-B+P493 SYN|m ASAL|FBal0066331==Abd-B+ DT|4 Feb 1998 |4 Feb 1998 ASGN|FBgn0000015==Abd-B REFDSR { RDID|FBrf0049804 |Celniker et al. |1989 AAL|491 PSZ|54 ABOD|monoclonal AGT|FBal0013553==Pc3 |Abd-B- | Df(3R)C4/Df(3R)P9 PCL|FBgn0000015==Abd-B protein is detected in embryonic nuclear extracts. BODP|FBgn0000015==Abd-B protein is expressed in the embryo starting in stage 8. It is | detected in the ectoderm and mesoderm of parasegments 13-15 and in the | mesoderm of parasegments 11 and 12. It is strongly expressed in the CNS at | germband retraction. CNS staining is strongest in parasegment 14 and | diminishes in parasegments 12 and 13. It is also expressed in Malpighian | tubules, in the visceral mesoderm, in cells surrounding the posterior | spiracles, and in the proctodeal primordium. In FBgn0003042==Pc embryos, FBgn0000015==Abd-B | protein can be detected in the ectoderm and neuromeres of all segments. No | labeling is observed in FBgn0000015==Abd-B[-]@ embryos. ASM|immunolocalization CVBODP| E | mid-late parasegment 13..15 ectoderm

| E | mid-late parasegment 11..15 mesoderm

| E | mid-late parasegment 12..14 embryonic central nervous system | presumptive

| E | mid-late visceral mesoderm

| E | mid-late Malpighian tubule

| E | mid-late spiracle

| E | mid-late proctodeum

CVCEL|nucleus ASTR|FBtr0002266==Abd-B+R4.5 |FBtr0002267==Abd-B+R4.8 CC|The expression pattern is a composite pattern for the ABD-BI and ABD-BII | proteins. The FBgn0000015==Abd-B protein homeodomain is no more than 55% identical to | any other Drosophila homeodomain. } REFDSR { RDID|FBrf0053790 |Boulet et al. |1991 PSZ|55 ABOD|polyclonal BODP|The level of protein is highest in parasegment 13 at stage 12 and is high in | parasegments 11-13 at later stages. ASM|immunolocalization CVBODP| E | stage 12 parasegment 13

| E | stage >12 parasegment 11..13

ASTR|FBtr0002266==Abd-B+R4.5 |FBtr0002267==Abd-B+R4.8 CC|Antibodies that recognize both the 272aa and 493aa FBgn0000015==Abd-B proteins were | made as well as an antibody specific to the 493aa form of the protein. } REFDSR { RDID|FBrf0054623 |Ali and Bienz |1991 CC|ABD-BI corresponds to ABD-BII with a large N-terminal extension; the two | proteins contain the same homeodomain. There are two strong transcriptional | activation domains in the common part of the two proteins. The | ABD-BI-specific exon contains additional transcriptional activation | potential, although it is a weaker transcriptional activator than the | ABD-BII, apparently due to inhibitory sequences in the ABD-BI-specific | exon. } REFDSR { RDID|FBrf0105495 |FlyBase |1992- DBA|NA:U31961 |PA:AAA84402 } REF { REFM|FBrf0049804 |Celniker et al. |1989 REFM|FBrf0053790 |Boulet et al. |1991 REFM|FBrf0054623 |Ali and Bienz |1991 REFM|FBrf0105495 |FlyBase |1992- } } # EOR PPR { RETE|ID 1 FBpp0003608 SYM 1 Abi-P1 AAL 1 473 PSZ 1 52 HG 1 + DBA 1 + REF 1 2 DT 1 30 May 2001 RESZ 876 ID|FBpp0003608 SYM|Abi-P1 ASAL|FBal0079502==Abi+ DT|30 May 2001 |30 May 2001 ARGS|FBgn0020510 DARTS|FBtr0082910 ASGN|FBgn0020510==Abi REFDSR { RDID|FBrf0104946 |FlyBase |1996- ASTR|FBtr0082910==Abi-RA } REFDSR { RDID|FBrf0111395 |Juang and Hoffmann |1999 AAL|473 PSZ|52 | observed HG|Homo sapiens | e3B1 |Homo sapiens | hAbi2 |Homo sapiens | hArgBP1A DBA|NA:AF151115 |PA:AAD38382 ASTR|FBtr0082910==Abi-RA CC|FBgn0020510==Abi protein is phosphorylated by FBgn0000017==Abl PTKs. FBgn0000017==Abl protein PTK kinase | activity is activated by FBgn0020510==Abi protein. The SH3 domain of FBgn0020510==Abi protein is | required for the activation. } REF { REFM|FBrf0104946 |FlyBase |1996- REFM|FBrf0111395 |Juang and Hoffmann |1999 } } # EOR PPR { RETE|ID 1 FBpp0082371 SYM 1 Abi-PA AAL 1 473 PSZ 1 - HG 1 - DBA 1 - REF 1 1 DT 1 5 Jun 2004 RESZ 279 ID|FBpp0082371 SYM|Abi-PA SYN|CG9749-PA ASAL|FBal0079502==Abi+ DT|5 Jun 2004 |5 Jun 2004 ASGN|FBgn0020510==Abi REFDSR { RDID|FBrf0166453 |FlyBase Genome Annotators |2004 AAL|473 } REF { REFM|FBrf0166453 |FlyBase Genome Annotators |2004 } } # EOR PPR { RETE|ID 1 FBpp0075116 SYM 1 Abl-PA AAL 1 1620 PSZ 1 - HG 1 - DBA 1 - REF 1 1 DT 1 5 Jun 2004 RESZ 320 ID|FBpp0075116 SYM|Abl-PA SYN|CG4032-PA ASAL|FBal0066332==Abl+ DT|5 Jun 2004 |5 Jun 2004 ASGN|FBgn0000017==Abl REFDSR { RDID|FBrf0166453 |FlyBase Genome Annotators |2004 AAL|1620 ASTR|FBtr0075357==Abl-RA } REF { REFM|FBrf0166453 |FlyBase Genome Annotators |2004 } } # EOR PPR { RETE|ID 1 FBpp0000021 SYM 1 Abl+P1520 AAL 1 - PSZ 1 180 HG 1 - DBA 1 + REF 1 5 DT 1 30 May 2001 RESZ 1068 ID|FBpp0000021 SYM|Abl+P1520 ASAL|FBal0066332==Abl+ DT|30 May 2001 |4 Feb 1998 ASGN|FBgn0000017==Abl REFDSR { RDID|FBrf0051398 |Henkemeyer et al. |1990 PSZ|180 CVBODP| E embryonic central nervous system

CVCEL|axon CC|Studies of mutated FBgn0000017==Abl proteins reveal that sequences in the carboxy | terminus mediate axonal localization. Disruption of proper subcellular | localization correlates with lack of FBgn0000017==Abl biological function. A novel | kinase-independent function of the FBgn0000017==Abl protein has been identified. } REFDSR { RDID|FBrf0080046 |Gertler et al. |1995 CC|enb protein is a substrate for FBgn0000017==Abl tyrosine kinase. } REFDSR { RDID|FBrf0105495 |FlyBase |1992- DBA|NA:M19692 |PA:AAA28934 } REF { REFM|FBrf0051398 |Henkemeyer et al. |1990 REFM|FBrf0051472 |Wadsworth |1990 REFM|FBrf0080046 |Gertler et al. |1995 REFM|FBrf0105495 |FlyBase |1992- REFM|FBrf0111395 |Juang and Hoffmann |1999 } } # EOR PPR { RETE|ID 1 FBpp0079757 SYM 1 abo-PA AAL 1 539 PSZ 1 - HG 1 - DBA 1 - REF 1 1 DT 1 5 Jun 2004 RESZ 319 ID|FBpp0079757 SYM|abo-PA SYN|CG6093-PA ASAL|FBal0068537==abo+ DT|5 Jun 2004 |5 Jun 2004 ASGN|FBgn0000018==abo REFDSR { RDID|FBrf0166453 |FlyBase Genome Annotators |2004 AAL|539 ASTR|FBtr0080168==abo-RA } REF { REFM|FBrf0166453 |FlyBase Genome Annotators |2004 } } # EOR PPR { RETE|ID 1 FBpp0078606 SYM 1 abs-PA AAL 1 619 PSZ 1 - HG 1 - DBA 1 - REF 1 1 DT 1 5 Jun 2004 RESZ 320 ID|FBpp0078606 SYM|abs-PA SYN|CG14637-PA ASAL|FBal0075245==abs+ DT|5 Jun 2004 |5 Jun 2004 ASGN|FBgn0015331==abs REFDSR { RDID|FBrf0166453 |FlyBase Genome Annotators |2004 AAL|619 ASTR|FBtr0078967==abs-RA } REF { REFM|FBrf0166453 |FlyBase Genome Annotators |2004 } } # EOR PPR { RETE|ID 1 FBpp0003233 SYM 1 abs+P619 AAL 1 619 PSZ 1 72 HG 1 - DBA 1 + REF 1 1 DT 1 22 Aug 2000 RESZ 414 ID|FBpp0003233 SYM|abs+P619 ASAL|FBal0075245==abs+ DT|22 Aug 2000 |22 Aug 2000 ASGN|FBgn0015331==abs REFDSR { RDID|FBrf0127310 |Schmucker et al. |2000 AAL|619 PSZ|72 | predicted PDOM|DEAD-box subfamily ATP-dependent helicase protein DBA|NA:AF212866 |PA:AAF19985 ASTR|FBtr0006135==abs+R2.0 } REF { REFM|FBrf0127310 |Schmucker et al. |2000 } } # EOR PPR { RETE|ID 1 FBpp0002631 SYM 1 ac-P* AAL 1 - PSZ 1 - HG 1 - DBA 1 - REF 1 1 DT 1 5 Nov 1999 RESZ 581 ID|FBpp0002631 SYM|ac-P* ASAL|FBal0068541==ac+ DT|5 Nov 1999 |22 Apr 1999 ASGN|FBgn0000022==ac REFDSR { RDID|FBrf0076492 |Singson et al. |1994 CC|FBgn0000413==da protein alone or in combination with FBgn0000022==ac protein or FBgn0004170==sc protein binds | in vitro to E-box sequences from the FBgn0000216==Brd, FBgn0000591==E(spl), FBgn0002633==HLHm7, and FBgn0003326==sca promoters. } REF { REFM|FBrf0076492 |Singson et al. |1994 } } # EOR PPR { RETE|ID 1 FBpp0000023 SYM 1 ac-P1 AAL 1 - PSZ 1 23 HG 1 - DBA 1 + REF 1 14 DT 1 23 Feb 2000 RESZ 6294 ID|FBpp0000023 SYM|ac-P1 SYN|ac+P201 ASAL|FBal0068541==ac+ DT|23 Feb 2000 |4 Feb 1998 ARGS|FBgn0000022 DARTS|FBtr0070072 ABODURL|anti-achaete.html anti-achaete ASGN|FBgn0000022==ac REFDSR { RDID|FBrf0045760 |Villares and Cabrera |1987 PSZ|23 | predicted ASTR|FBtr0070072==ac-RA } REFDSR { RDID|FBrf0053776 |van Doren et al. |1991 CC|Heterodimers between the FBgn0000413==da protein and either the FBgn0000022==ac, FBgn0004170==sc, or FBgn0002561==l(1)sc | proteins were found to bind specifically to E box consensus sequences in | the FBgn0000022==ac promoter region in vitro. The three heterodimers had differing | affinities for the E boxes acE1-acE3 and none bound to FBgn0000022==acE4. This | binding was inhibited in a concentration dependent manner by the FBgn0000575==emc protein. } REFDSR { RDID|FBrf0053886 |Cabrera and Alonso |1991 CC|FBgn0000022==ac-FBgn0000413==da and FBgn0004170==sc-FBgn0000413==da protein heterodimers form | and bind strongly to target sequences in the FBgn0001180==hb and FBgn0000022==ac promoters. FBgn0000022==ac | protein will not form homodimers or heterodimers with FBgn0004170==sc or FBgn0002561==l(1)sc proteins. } REFDSR { RDID|FBrf0054073 |Skeath and Carroll |1991 AGT|FBal0005336==h19 |FBal0005343==h26 |FBal0031198==emcE12 |FBal0003688==emc11 |Df(1)sc8Lsc4R BODP|FBgn0000022==ac protein expression occurs in clusters of cells from which SMCs will | arise. It is transiently expressed in the SMCs, often at greater levels | than the surrounding cells of the proneural cluster, but not in their | progeny. In FBgn0004170==sc mutants, AC expression is missing in the notal cells that | give rise to FBgn0004170==sc-dependent machrochaetes. In FBgn0000575==emc mutants, ectopic AC | expression occurs in single cells of the notum that will give rise to | ectopic sensory organs. In FBgn0001168==h mutants ectopic AC expression occurs in | regions of the imaginal wing blade that will give rise to ectopic sensory | organs. Ectopic FBgn0001168==h expression represses FBgn0000022==ac expression. An FBal0000172==ac[Hw-49c] | mutation causes overexpression of AC. ASM|immunolocalization CVBODP| L | third instar dorsal mesothoracic disc

| L | third instar sensory organ mother cell

| L | third instar ectoderm

| L | third instar proneural cluster

| L | third instar wing vein L1

} REFDSR { RDID|FBrf0054074 |Cubas et al. |1991 BODP|FBgn0000022==ac protein is localized within nuclei of proneural clusters. Clusters grow | in number and intensity of staining until the sensory organ mother cell | (SMC) becomes discernable due to its more intensely stained nucleus. The | FBgn0000022==ac protein disappears shortly before the SMC undergoes its first | differential division. ASM|immunolocalization CVBODP| L dorsal mesothoracic disc

| L proneural cluster

CVCEL|nucleus CC|The pattern and timing of expression in specific clusters is discussed. } REFDSR { RDID|FBrf0055900 |Doe |1992 BODP|The FBgn0000022==ac protein is expressed in a specified subset of neuroblasts in | embryonic stages 8-11. (see also FBrf 55911) ASM|immunolocalization CVBODP| E | stage 8-10 neuroblast MP2

| E | stage 8-9 neuroblast NB3-5

| E | stage 8-9 neuroblast NB7-1

| E | stage 8-9 neuroblast NB7-4

} REFDSR { RDID|FBrf0055911 |Skeath and Carroll |1992 ABOD|monoclonal BODP|FBgn0000022==ac protein first accumulates in late stage 8 embryos in a segmentally | repeated pattern of two medial and two lateral clusters of 5-7 ectodermal | cells per hemisegment. One cell per cluster, the future neuroblast, comes | to express FBgn0000022==ac most intensely and delaminates toward the interior of the | embryo. The remaining cells in the ectodermal cluster lose FBgn0000022==ac protein | expression. Expression of FBgn0000022==ac protein in the neuroblast ceases after it | has delaminated from the ectoderm and before it begins dividing. In mutants | of FBgn0004647==N, FBgn0000463==Dl, FBgn0000180==bib, FBgn0002932==neur, and FBgn0000591==E(spl), most to all cells of the cluster | retain FBgn0000022==ac protein expression at high levels. ASM|immunolocalization CVBODP| E | stage 8 ectoderm

| E | stage 9 neuroblast

CVCEL|nucleus ASTR|FBtr0070072==ac-RA } REFDSR { RDID|FBrf0057141 |Blair et al. |1992 BODP|Expression of FBgn0000022==ac and FBgn0004170==sc in ectopic sensilla of FBgn0001168==h and ac[Hw*] mutants | was followed with antibody staining. The pattern of expression of FBgn0000022==ac and | FBgn0004170==sc prefigures the pattern of both ectopic and normal sensilla. } REFDSR { RDID|FBrf0101931 |Kehl et al. |1998 MRK|sensillum precursor } REFDSR { RDID|FBrf0104946 |FlyBase |1996- ASTR|FBtr0070072==ac-RA } REFDSR { RDID|FBrf0105495 |FlyBase |1992- DBA|NA:M17120 |PA:AAA28312 } REF { REFM|FBrf0000000Flybase Curation REFM|FBrf0045760 |Villares and Cabrera |1987 REFM|FBrf0053776 |van Doren et al. |1991 REFM|FBrf0053886 |Cabrera and Alonso |1991 REFM|FBrf0054073 |Skeath and Carroll |1991 REFM|FBrf0054074 |Cubas et al. |1991 REFM|FBrf0055900 |Doe |1992 REFM|FBrf0055911 |Skeath and Carroll |1992 REFM|FBrf0057141 |Blair et al. |1992 REFM|FBrf0075104 |Cabrera et al. |1994 REFM|FBrf0101931 |Kehl et al. |1998 REFM|FBrf0104946 |FlyBase |1996- REFM|FBrf0105495 |FlyBase |1992- REFM|FBrf0123097 |Lai et al. |2000 } } # EOR PPR { RETE|ID 1 FBpp0070071 SYM 1 ac-PA AAL 1 201 PSZ 1 - HG 1 - DBA 1 - REF 1 1 DT 1 5 Jun 2004 RESZ 276 ID|FBpp0070071 SYM|ac-PA SYN|CG3796-PA ASAL|FBal0068541==ac+ DT|5 Jun 2004 |5 Jun 2004 ASGN|FBgn0000022==ac REFDSR { RDID|FBrf0166453 |FlyBase Genome Annotators |2004 AAL|201 } REF { REFM|FBrf0166453 |FlyBase Genome Annotators |2004 } } # EOR PPR { RETE|ID 1 FBpp0085252 SYM 1 Ac3-PA AAL 1 1167 PSZ 1 - HG 1 - DBA 1 - REF 1 1 DT 1 5 Jun 2004 RESZ 320 ID|FBpp0085252 SYM|Ac3-PA SYN|CG1506-PA ASAL|FBal0087452==Ac3+ DT|5 Jun 2004 |5 Jun 2004 ASGN|FBgn0023416==Ac3 REFDSR { RDID|FBrf0166453 |FlyBase Genome Annotators |2004 AAL|1167 ASTR|FBtr0085897==Ac3-RA } REF { REFM|FBrf0166453 |FlyBase Genome Annotators |2004 } } # EOR PPR { RETE|ID 1 FBpp0085253 SYM 1 Ac3-PB AAL 1 1167 PSZ 1 - HG 1 - DBA 1 - REF 1 1 DT 1 5 Jun 2004 RESZ 320 ID|FBpp0085253 SYM|Ac3-PB SYN|CG1506-PB ASAL|FBal0087452==Ac3+ DT|5 Jun 2004 |5 Jun 2004 ASGN|FBgn0023416==Ac3 REFDSR { RDID|FBrf0166453 |FlyBase Genome Annotators |2004 AAL|1167 ASTR|FBtr0085898==Ac3-RB } REF { REFM|FBrf0166453 |FlyBase Genome Annotators |2004 } } # EOR PPR { RETE|ID 1 FBpp0003136 SYM 1 Ac3+P352 AAL 1 352 PSZ 1 35 HG 1 - DBA 1 - REF 1 1 DT 1 16 Aug 2000 RESZ 801 ID|FBpp0003136 SYM|Ac3+P352 SYN|DAC39Etrunc ASAL|FBal0087452==Ac3+ DT|16 Aug 2000 |16 Aug 2000 ASGN|FBgn0023416==Ac3 REFDSR { RDID|FBrf0125164 |Iourgenko and Levin |2000 AAL|352 PSZ|35 | observed ABOD|polyclonal ASM|western blot CVBODP|western blot | E | 10-18 hr

ASTR|FBtr0005998==Ac3+R6.0B CC|The longer FBgn0023416==Ac3 protein is predicted to have two sets of six transmembrane | (TM) domains, each followed by a catalytic domain. The shorter FBgn0023416==Ac3 | protein is predicted to have only one of the two sets of TM domains, and | none of the residues thought to be necessary for adenylate cyclase activity. } REF { REFM|FBrf0125164 |Iourgenko and Levin |2000 } } # EOR PPR { RETE|ID 1 FBpp0003135 SYM 1 Ac3+P1167 AAL 1 1167 PSZ 1 140 HG 1 + DBA 1 + REF 1 1 DT 1 16 Aug 2000 RESZ 1667 ID|FBpp0003135 SYM|Ac3+P1167 SYN|DAC39Efl ASAL|FBal0087452==Ac3+ DT|16 Aug 2000 |16 Aug 2000 ASGN|FBgn0023416==Ac3 REFDSR { RDID|FBrf0125164 |Iourgenko and Levin |2000 AAL|1167 PSZ|140 | observed HG|Rattus norvegicus | AC3 (SWP:P21932) ABOD|polyclonal BODP|FBgn0023416==Ac3 protein is expressed predominantly in the central nervous system and | olfactory organs. ASM|western blot |immunolocalization CVBODP|western blot | A

| A adult head

| A antenna

|immunolocalization | A neuropil

| A adult brain

| A optic lobe neuron

| A antennal lobe

| A suboesophageal ganglion

PDOM|Guanylate cyclases signature. DBA|NA:AF005629 |PA:AAD01252 ASTR|FBtr0005997==Ac3+R6.0A CC|The longer FBgn0023416==Ac3 protein is predicted to have two sets of six transmembrane | (TM) domains, each followed by a catalytic domain. The shorter FBgn0023416==Ac3 | protein is predicted to have only one of the two sets of TM domains, and | none of the residues thought to be necessary for adenylate cyclase (AC) | activity. Full-length FBgn0023416==Ac3 protein has AC activity in in vitro assays. | But FBgn0023416==Ac3 protein is inhibited by calcium in the presence of calmodulin, | while FBgn0003301==rut AC is stimulated under the same conditions. Unlike rat AC3, | FBgn0023416==Ac3 protein AC activity is not modulated by FBgn0004624==CaMKII. } REF { REFM|FBrf0125164 |Iourgenko and Levin |2000 } } # EOR PPR { RETE|ID 1 FBpp0003641 SYM 1 Ac13E-P1 AAL 1 1690 PSZ 1 - HG 1 + DBA 1 + REF 1 2 DT 1 18 Jul 2001 RESZ 669 ID|FBpp0003641 SYM|Ac13E-P1 ASAL|FBal0101903==Ac13E+ DT|18 Jul 2001 |5 Jun 2001 ARGS|FBgn0022710 DARTS|FBtr0074073 ASGN|FBgn0022710==Ac13E REFDSR { RDID|FBrf0098273 |Iourgenko et al. |1997 AAL|1708 HG|Mus | AC9 |Xenopus laevis | xlAC |C. elegans | ceAC DBA|NA:AF005630 |PA:AAB70469 ASTR|FBtr0074073==Ac13E-RA CC|FBgn0022710==Ac13E protein was biochemically characterized and shown to have adenylyl | cyclase activity. } REFDSR { RDID|FBrf0104946 |FlyBase |1996- AAL|1690 ASTR|FBtr0074073==Ac13E-RA } REF { REFM|FBrf0098273 |Iourgenko et al. |1997 REFM|FBrf0104946 |FlyBase |1996- } } # EOR PPR { RETE|ID 1 FBpp0073889 SYM 1 Ac13E-PA AAL 1 1690 PSZ 1 - HG 1 - DBA 1 - REF 1 1 DT 1 5 Jun 2004 RESZ 286 ID|FBpp0073889 SYM|Ac13E-PA SYN|CG9210-PA ASAL|FBal0101903==Ac13E+ DT|5 Jun 2004 |5 Jun 2004 ASGN|FBgn0022710==Ac13E REFDSR { RDID|FBrf0166453 |FlyBase Genome Annotators |2004 AAL|1690 } REF { REFM|FBrf0166453 |FlyBase Genome Annotators |2004 } } # EOR PPR { RETE|ID 1 FBpp0074666 SYM 1 Ac76E-PA AAL 1 1307 PSZ 1 - HG 1 - DBA 1 - REF 1 1 DT 1 5 Jun 2004 RESZ 328 ID|FBpp0074666 SYM|Ac76E-PA SYN|CG7978-PA ASAL|FBal0066335==Ac76E+ DT|5 Jun 2004 |5 Jun 2004 ASGN|FBgn0004852==Ac76E REFDSR { RDID|FBrf0166453 |FlyBase Genome Annotators |2004 AAL|1307 ASTR|FBtr0074897==Ac76E-RA } REF { REFM|FBrf0166453 |FlyBase Genome Annotators |2004 } } # EOR PPR { RETE|ID 1 FBpp0077978 SYM 1 Ac78C-PA AAL 1 1694 PSZ 1 - HG 1 - DBA 1 - REF 1 1 DT 1 5 Jun 2004 RESZ 329 ID|FBpp0077978 SYM|Ac78C-PA SYN|CG10564-PA ASAL|FBal0088154==Ac78C+ DT|5 Jun 2004 |5 Jun 2004 ASGN|FBgn0024150==Ac78C REFDSR { RDID|FBrf0166453 |FlyBase Genome Annotators |2004 AAL|1694 ASTR|FBtr0078322==Ac78C-RA } REF { REFM|FBrf0166453 |FlyBase Genome Annotators |2004 } } # EOR PPR { RETE|ID 1 FBpp0003133 SYM 1 Ac78C+P1222 AAL 1 1222 PSZ 1 - HG 1 - DBA 1 + REF 1 1 DT 1 16 Aug 2000 RESZ 667 ID|FBpp0003133 SYM|Ac78C+P1222 ASAL|FBal0088154==Ac78C+ DT|16 Aug 2000 |16 Aug 2000 ASGN|FBgn0024150==Ac78C REFDSR { RDID|FBrf0122985 |Cann and Levin |2000 AAL|1222 PDOM|Guanylate cyclases signature.(PS00452) DBA|NA:AF047382 |PA:AAD46380 ASTR|FBtr0005995==Ac78C+R4.5 CC|No adenylate cyclase activity was demonstrated in vitro for the shorter | FBgn0024150==Ac78C protein isoform that contains the adenylate cyclase catalytic | domains but that lacks the first six of the 12 transmembrane domains | present in the longer isoform. } REF { REFM|FBrf0122985 |Cann and Levin |2000 } } # EOR PPR { RETE|ID 1 FBpp0003132 SYM 1 Ac78C+P1718 AAL 1 1718 PSZ 1 - HG 1 - DBA 1 + REF 1 1 DT 1 16 Aug 2000 RESZ 464 ID|FBpp0003132 SYM|Ac78C+P1718 ASAL|FBal0088154==Ac78C+ DT|16 Aug 2000 |16 Aug 2000 ASGN|FBgn0024150==Ac78C REFDSR { RDID|FBrf0122985 |Cann and Levin |2000 AAL|1718 PDOM|Guanylate cyclases signature.(PS00452) DBA|NA:AF047382 |PA:AAD44018 ASTR|FBtr0005994==Ac78C+R6.5 CC|Ac78C protein Catalyzes the synthesis of cAMP in vitro. } REF { REFM|FBrf0122985 |Cann and Levin |2000 } } # EOR PPR { RETE|ID 1 FBpp0003568 SYM 1 ac+P AAL 1 - PSZ 1 - HG 1 - DBA 1 - REF 1 1 DT 1 23 Apr 2001 RESZ 185 ID|FBpp0003568 SYM|ac+P ASAL|FBal0068541==ac+ DT|23 Apr 2001 |23 Apr 2001 ASGN|FBgn0000022==ac REF { REFM|FBrf0105495 |FlyBase |1992- } } # EOR PPR { RETE|ID 1 FBpp0078067 SYM 1 AcCoAS-PA AAL 1 670 PSZ 1 - HG 1 - DBA 1 - REF 1 1 DT 1 5 Jun 2004 RESZ 331 ID|FBpp0078067 SYM|AcCoAS-PA SYN|CG9390-PA ASAL|FBal0071532==AcCoAS+ DT|5 Jun 2004 |5 Jun 2004 ASGN|FBgn0012034==AcCoAS REFDSR { RDID|FBrf0166453 |FlyBase Genome Annotators |2004 AAL|670 ASTR|FBtr0078413==AcCoAS-RA } REF { REFM|FBrf0166453 |FlyBase Genome Annotators |2004 } } # EOR PPR { RETE|ID 1 FBpp0078068 SYM 1 AcCoAS-PB AAL 1 524 PSZ 1 - HG 1 - DBA 1 - REF 1 1 DT 1 5 Jun 2004 RESZ 331 ID|FBpp0078068 SYM|AcCoAS-PB SYN|CG9390-PB ASAL|FBal0071532==AcCoAS+ DT|5 Jun 2004 |5 Jun 2004 ASGN|FBgn0012034==AcCoAS REFDSR { RDID|FBrf0166453 |FlyBase Genome Annotators |2004 AAL|524 ASTR|FBtr0078414==AcCoAS-RB } REF { REFM|FBrf0166453 |FlyBase Genome Annotators |2004 } } # EOR PPR { RETE|ID 1 FBpp0000024 SYM 1 AcCoAS+P581 AAL 1 - PSZ 1 - HG 1 - DBA 1 + REF 1 1 DT 1 4 Feb 1998 RESZ 270 ID|FBpp0000024 SYM|AcCoAS+P581 ASAL|FBal0071532==AcCoAS+ DT|4 Feb 1998 |4 Feb 1998 ASGN|FBgn0012034==AcCoAS REFDSR { RDID|FBrf0105495 |FlyBase |1992- DBA|NA:Z46786 |PA:CAA86738 } REF { REFM|FBrf0105495 |FlyBase |1992- } } # EOR PPR { RETE|ID 1 FBpp0000025 SYM 1 Ace-P1 AAL 1 - PSZ 1 - HG 1 - DBA 1 + REF 1 5 DT 1 21 Aug 2001 RESZ 2160 ID|FBpp0000025 SYM|Ace-P1 SYN|Ace+P649 ASAL|FBal0066336==Ace+ DT|21 Aug 2001 |4 Feb 1998 ARGS|FBgn0000024 DARTS|FBtr0082780 ASGN|FBgn0000024==Ace REFDSR { RDID|FBrf0050439 |Fournier et al. |1989 ASTR|FBtr0082780==Ace-RA } REFDSR { RDID|FBrf0056003 |Fournier et al. |1992 CC|When FBgn0000024==Ace cDNA is injected into Xenopus oocytes, a protein is formed which | is biochemically similar to the Drosophila head FBgn0000024==Ace protein. However, the | hydrophobic C-terminal peptide is not replaced by a glycolipid anchor as | occurs in the normal maturation process. As a consequence, the enzyme is no | longer externalized, proteolytic cutting of the main peptide does not occur | and a new polymerization form occurs. Although incompletely processed, it | is enzymatically active. When a cDNA lacking the C-terminal hydrophobic | peptide is injected, the resulting protein is hydrophilic and is cleaved | into two subunits that are secreted into the incubation medium. } REFDSR { RDID|FBrf0056403 |Fournier et al. |1992 CC|FBgn0000024==Ace protein activity was measured in strains carrying wild type and/or | mutant copies of the FBgn0000024==Ace gene with or without an additional minigene | construct. These display a range of activity levels and are used to show | that resistance to organophosphorus compounds is correlated with the amount | of acetylcholinesterase in the CNS. } REFDSR { RDID|FBrf0057375 |Mutero et al. |1992 ASTR|FBtr0082780==Ace-RA CC|Tyrosine 109 is thought to contribute to the conformation of the active site | and the charge of this residue is important for catalytic properties. The | effects of various mutations at this site on catalytic parameters, pH | activity profiles, and protein stability were studied. } REFDSR { RDID|FBrf0105495 |FlyBase |1992- DBA|NA:X05893 |PA:CAA29326 } REF { REFM|FBrf0050439 |Fournier et al. |1989 REFM|FBrf0056003 |Fournier et al. |1992 REFM|FBrf0056403 |Fournier et al. |1992 REFM|FBrf0057375 |Mutero et al. |1992 REFM|FBrf0105495 |FlyBase |1992- } } # EOR PPR { RETE|ID 1 FBpp0082248 SYM 1 Ace-PA AAL 1 649 PSZ 1 - HG 1 - DBA 1 - REF 1 1 DT 1 5 Jun 2004 RESZ 280 ID|FBpp0082248 SYM|Ace-PA SYN|CG17907-PA ASAL|FBal0066336==Ace+ DT|5 Jun 2004 |5 Jun 2004 ASGN|FBgn0000024==Ace REFDSR { RDID|FBrf0166453 |FlyBase Genome Annotators |2004 AAL|649 } REF { REFM|FBrf0166453 |FlyBase Genome Annotators |2004 } } # EOR PPR { RETE|ID 1 FBpp0001972 SYM 1 Ace+P57kD AAL 1 - PSZ 1 57 HG 1 - DBA 1 - REF 1 1 DT 1 20 Mar 1998 RESZ 763 ID|FBpp0001972 SYM|Ace+P57kD ASAL|FBal0066336==Ace+ DT|20 Mar 1998 |10 Mar 1998 ASGN|FBgn0000024==Ace REFDSR { RDID|FBrf0048343 |Krishnan |1988 PSZ|57 BODP|Developmental profiles of enzyme activity were carried out. The soluble form | is seen only in pupae and adults. CC|The FBgn0000024==Ace enzyme exists in two different forms, a soluble form and a | membrane-bound form. The membrane form is a tetramer consisting of two 64kD | subunits and a disulphide-linked dimer of 60kD and 57kD subunits. The | soluble species is a dimer of 66kD and 64kD subunits. It appears that | cooperation between nonidentical subunits is needed for activity (this study). } REF { REFM|FBrf0048343 |Krishnan |1988 } } # EOR PPR { RETE|ID 1 FBpp0001971 SYM 1 Ace+P60kD AAL 1 - PSZ 1 60 HG 1 - DBA 1 - REF 1 1 DT 1 20 Mar 1998 RESZ 760 ID|FBpp0001971 SYM|Ace+P60kD ASAL|FBal0066336==Ace+ DT|20 Mar 1998 |10 Mar 1998 ASGN|FBgn0000024==Ace REFDSR { RDID|FBrf0048343 |Krishnan |1988 PSZ|60 BODP|Development profiles of enzyme activity were carried out. The soluble form | is seen only in pupae an adults. CC|The FBgn0000024==Ace enzyme exists in two different forms, a soluble form and a | membrane-bound form. The membrane form is a tetramer consisting of two 64kD | subunits and a disulphide-linked dimer of 60kD and 57kD subunits. The | soluble species is a dimer of 66kD and 64kD subunits. It appears that | cooperation between nonidentical subunits is needed for activity (this study). } REF { REFM|FBrf0048343 |Krishnan |1988 } } # EOR PPR { RETE|ID 1 FBpp0001970 SYM 1 Ace+P64kD AAL 1 - PSZ 1 64 HG 1 - DBA 1 - REF 1 1 DT 1 20 Mar 1998 RESZ 763 ID|FBpp0001970 SYM|Ace+P64kD ASAL|FBal0066336==Ace+ DT|20 Mar 1998 |10 Mar 1998 ASGN|FBgn0000024==Ace REFDSR { RDID|FBrf0048343 |Krishnan |1988 PSZ|64 BODP|Developmental profiles of enzyme activity were carried out. The soluble form | is seen only in pupae and adults. CC|The FBgn0000024==Ace enzyme exists in two different forms, a soluble form and a | membrane-bound form. The membrane form is a tetramer consisting of two 64kD | subunits and a disulphide-linked dimer of 60kD and 57kD subunits. The | soluble species is a dimer of 66kD and 64kD subunits. It appears that | cooperation between nonidentical subunits is needed for activity (this study). } REF { REFM|FBrf0048343 |Krishnan |1988 } } # EOR PPR { RETE|ID 1 FBpp0001973 SYM 1 Ace+P66kD AAL 1 - PSZ 1 66 HG 1 - DBA 1 - REF 1 1 DT 1 20 Mar 1998 RESZ 763 ID|FBpp0001973 SYM|Ace+P66kD ASAL|FBal0066336==Ace+ DT|20 Mar 1998 |10 Mar 1998 ASGN|FBgn0000024==Ace REFDSR { RDID|FBrf0048343 |Krishnan |1988 PSZ|66 BODP|Developmental profiles of enzyme activity were carried out. The soluble form | is seen only in pupae and adults. CC|The FBgn0000024==Ace enzyme exists in two different forms, a soluble form and a | membrane-bound form. The membrane form is a tetramer consisting of two 64kD | subunits and a disulphide-linked dimer of 60kD and 57kD subunits. The | soluble species is a dimer of 66kD and 64kD subunits. It appears that | cooperation between nonidentical subunits is needed for activity (this study). } REF { REFM|FBrf0048343 |Krishnan |1988 } } # EOR PPR { RETE|ID 1 FBpp0000026 SYM 1 Acer-P1 AAL 1 630 PSZ 1 - HG 1 + DBA 1 + REF 1 3 DT 1 4 Feb 2000 RESZ 646 ID|FBpp0000026 SYM|Acer-P1 SYN|Acer+P630 ASAL|FBal0075872==Acer+ DT|4 Feb 2000 |4 Feb 1998 ARGS|FBgn0016122 DARTS|FBtr0079685 ASGN|FBgn0016122==Acer REFDSR { RDID|FBrf0091185 |Taylor et al. |1996 AAL|630 HG|rabiit | tACE |Homo sapiens | Ance |mouse | Ance DBA|NA:X96913 |PA:CAA65632 ASTR|FBtr0079685==Acer-RA } REFDSR { RDID|FBrf0104946 |FlyBase |1996- ASTR|FBtr0079685==Acer-RA } REFDSR { RDID|FBrf0105495 |FlyBase |1992- DBA|NA:X96913 |PA:CAA65632 } REF { REFM|FBrf0091185 |Taylor et al. |1996 REFM|FBrf0104946 |FlyBase |1996- REFM|FBrf0105495 |FlyBase |1992- } } # EOR PPR { RETE|ID 1 FBpp0079297 SYM 1 Acer-PA AAL 1 630 PSZ 1 - HG 1 - DBA 1 - REF 1 1 DT 1 5 Jun 2004 RESZ 283 ID|FBpp0079297 SYM|Acer-PA SYN|CG10593-PA ASAL|FBal0075872==Acer+ DT|5 Jun 2004 |5 Jun 2004 ASGN|FBgn0016122==Acer REFDSR { RDID|FBrf0166453 |FlyBase Genome Annotators |2004 AAL|630 } REF { REFM|FBrf0166453 |FlyBase Genome Annotators |2004 } } # EOR PPR { RETE|ID 1 FBpp0085204 SYM 1 Acf1-PA AAL 1 1476 PSZ 1 - HG 1 - DBA 1 - REF 1 1 DT 1 5 Jun 2004 RESZ 324 ID|FBpp0085204 SYM|Acf1-PA SYN|CG1966-PA ASAL|FBal0099516==Acf1+ DT|5 Jun 2004 |5 Jun 2004 ASGN|FBgn0027620==Acf1 REFDSR { RDID|FBrf0166453 |FlyBase Genome Annotators |2004 AAL|1476 ASTR|FBtr0085845==Acf1-RA } REF { REFM|FBrf0166453 |FlyBase Genome Annotators |2004 } } # EOR PPR { RETE|ID 1 FBpp0003191 SYM 1 Acf1+P1476 AAL 1 1476 PSZ 1 170 HG 1 + DBA 1 + REF 1 1 DT 1 22 Aug 2000 RESZ 1037 ID|FBpp0003191 SYM|Acf1+P1476 ASAL|FBal0099516==Acf1+ DT|22 Aug 2000 |22 Aug 2000 ASGN|FBgn0027620==Acf1 REFDSR { RDID|FBrf0109981 |Ito et al. |1999 AAL|1476 PSZ|170 | predicted |170 | observed |185 | observed HG|Homo sapiens | WSTF (Williams syndrome transcription factor) ABOD|polyclonal BODP|FBgn0027620==Acf1 protein is detected throughout embryogenesis and at significantly | lower levels in larvae, pupae, and adults. ASM|western blot CVBODP|western blot | E-A

PDOM|PHD domain protein |Bromodomain protein DBA|NA:AF148962 |PA:AAD38952 ASTR|FBtr0006074==Acf1+R4.5 CC|FBgn0027620==Acf1 protein is a subunit of ACF (ATP-utilizing chromatin chromatin | assembly and remodeling factor). Purification of ACF, leads to isolation of | FBgn0027620==Acf1 protein and FBgn0011604==Iswi protein. The purified complex has chromatin | assembly activity. } REF { REFM|FBrf0109981 |Ito et al. |1999 } } # EOR PPR { RETE|ID 1 FBpp0087054 SYM 1 a&khgr;-PA AAL 1 426 PSZ 1 - HG 1 - DBA 1 - REF 1 1 DT 1 5 Jun 2004 RESZ 326 ID|FBpp0087054 SYM|a&khgr;-PA SYN|CG8819-PA ASAL|FBal0128364==achi+ DT|5 Jun 2004 |5 Jun 2004 ASGN|FBgn0033749==achi REFDSR { RDID|FBrf0166453 |FlyBase Genome Annotators |2004 AAL|426 ASTR|FBtr0087943==achi-RA } REF { REFM|FBrf0166453 |FlyBase Genome Annotators |2004 } } # EOR PPR { RETE|ID 1 FBpp0087053 SYM 1 a&khgr;-PC AAL 1 555 PSZ 1 - HG 1 - DBA 1 - REF 1 1 DT 1 5 Jun 2004 RESZ 326 ID|FBpp0087053 SYM|a&khgr;-PC SYN|CG8819-PC ASAL|FBal0128364==achi+ DT|5 Jun 2004 |5 Jun 2004 ASGN|FBgn0033749==achi REFDSR { RDID|FBrf0166453 |FlyBase Genome Annotators |2004 AAL|555 ASTR|FBtr0087942==achi-RC } REF { REFM|FBrf0166453 |FlyBase Genome Annotators |2004 } } # EOR PPR { RETE|ID 1 FBpp0073832 SYM 1 acj6-PA AAL 1 396 PSZ 1 - HG 1 - DBA 1 - REF 1 1 DT 1 5 Jun 2004 RESZ 323 ID|FBpp0073832 SYM|acj6-PA SYN|CG9151-PA ASAL|FBal0068546==acj6+ DT|5 Jun 2004 |5 Jun 2004 ASGN|FBgn0000028==acj6 REFDSR { RDID|FBrf0166453 |FlyBase Genome Annotators |2004 AAL|396 ASTR|FBtr0074015==acj6-RA } REF { REFM|FBrf0166453 |FlyBase Genome Annotators |2004 } } # EOR PPR { RETE|ID 1 FBpp0073833 SYM 1 acj6-PB AAL 1 375 PSZ 1 - HG 1 - DBA 1 - REF 1 1 DT 1 5 Jun 2004 RESZ 323 ID|FBpp0073833 SYM|acj6-PB SYN|CG9151-PB ASAL|FBal0068546==acj6+ DT|5 Jun 2004 |5 Jun 2004 ASGN|FBgn0000028==acj6 REFDSR { RDID|FBrf0166453 |FlyBase Genome Annotators |2004 AAL|375 ASTR|FBtr0074016==acj6-RB } REF { REFM|FBrf0166453 |FlyBase Genome Annotators |2004 } } # EOR PPR { RETE|ID 1 FBpp0000027 SYM 1 acj6+P367 AAL 1 367 PSZ 1 44 HG 1 - DBA 1 + REF 1 2 DT 1 4 Feb 1998 RESZ 1367 ID|FBpp0000027 SYM|acj6+P367 ASAL|FBal0068546==acj6+ DT|4 Feb 1998 |4 Feb 1998 ASGN|FBgn0000028==acj6 REFDSR { RDID|FBrf0054786 |Treacy et al. |1991 AAL|367 PSZ|44 ABOD|polyclonal ASTR|FBtr0001832==acj6+R1.7A CC|FBgn0000028==acj6 protein cannot bind DNA due to the lack of two basic amino acids in | the N-terminal region of its POU homeodomain that are present in other POU | doman genes. Immunoprecipitation and crosslinking studies show that FBgn0000028==acj6 | protein associates with FBgn0003995==vvl protein in vivo. When bound by FBgn0000028==acj6 protein | as a heterodimer, FBgn0003995==vvl protein no longer binds the enhancer site of the | FBgn0000422==Ddc gene. Transfection experiments in CV-1 cells demonstrate that FBgn0003995==vvl | protein activates transcription of a reporter gene driven by the FBgn0000422==Ddc | promoter or a heterologous promoter preceded by the FBgn0003995==vvl element. This | activation does not occur in the presence of FBgn0000028==acj6 protein. } REFDSR { RDID|FBrf0105495 |FlyBase |1992- DBA|NA:X58436 |PA:CAA41342 } REF { REFM|FBrf0054786 |Treacy et al. |1991 REFM|FBrf0105495 |FlyBase |1992- } } # EOR PPR { RETE|ID 1 FBpp0001930 SYM 1 acj6+P369 AAL 1 369 PSZ 1 - HG 1 - DBA 1 - REF 1 1 DT 1 20 Mar 1998 RESZ 973 ID|FBpp0001930 SYM|acj6+P369 SYN|tI-POU ASAL|FBal0068546==acj6+ DT|20 Mar 1998 |10 Mar 1998 ASGN|FBgn0000028==acj6 REFDSR { RDID|FBrf0055566 |Treacy et al. |1992 AAL|369 ASTR|FBtr0001832==acj6+R1.7A |FBtr0001834==acj6+R1.7B CC|"Twin of IPOU", produced from a splice variant of the Ipou gene, has 2 | additional basic residues (RK) with respect to IPOU which allow it to | specifically bind DNA. This form of the Ipou protein does not interact | with FBgn0003995==vvl protein but can act as a positive transcription factor on | targets distinct from those regulated by FBgn0003995==vvl protein. Isoforms IPOU and | twin of IPOU appear to exert complementary functions, simultaneously | activating and inhibiting two distinct sets of transcription units, respectively. } REF { REFM|FBrf0055566 |Treacy et al. |1992 } } # EOR PPR { RETE|ID 1 FBpp0073067 SYM 1 Ack-PA AAL 1 1073 PSZ 1 - HG 1 - DBA 1 - REF 1 1 DT 1 5 Jun 2004 RESZ 321 ID|FBpp0073067 SYM|Ack-PA SYN|CG14992-PA ASAL|FBal0116936==Ack+ DT|5 Jun 2004 |5 Jun 2004 ASGN|FBgn0028484==Ack REFDSR { RDID|FBrf0166453 |FlyBase Genome Annotators |2004 AAL|1073 ASTR|FBtr0073211==Ack-RA } REF { REFM|FBrf0166453 |FlyBase Genome Annotators |2004 } } # EOR PPR { RETE|ID 1 FBpp0081002 SYM 1 Acon-PB AAL 1 787 PSZ 1 - HG 1 - DBA 1 - REF 1 1 DT 1 5 Jun 2004 RESZ 323 ID|FBpp0081002 SYM|Acon-PB SYN|CG9244-PB ASAL|FBal0068550==Acon+ DT|5 Jun 2004 |5 Jun 2004 ASGN|FBgn0010100==Acon REFDSR { RDID|FBrf0166453 |FlyBase Genome Annotators |2004 AAL|787 ASTR|FBtr0081473==Acon-RB } REF { REFM|FBrf0166453 |FlyBase Genome Annotators |2004 } } # EOR PPR { RETE|ID 1 FBpp0071533 SYM 1 Acox57D-d-PA AAL 1 677 PSZ 1 - HG 1 - DBA 1 - REF 1 1 DT 1 5 Jun 2004 RESZ 343 ID|FBpp0071533 SYM|Acox57D-d-PA SYN|CG9709-PA ASAL|FBal0128370==Acox57D-d+ DT|5 Jun 2004 |5 Jun 2004 ASGN|FBgn0034629==Acox57D-d REFDSR { RDID|FBrf0166453 |FlyBase Genome Annotators |2004 AAL|677 ASTR|FBtr0071607==Acox57D-d-RA } REF { REFM|FBrf0166453 |FlyBase Genome Annotators |2004 } } # EOR PPR { RETE|ID 1 FBpp0071532 SYM 1 Acox57D-p-PA AAL 1 677 PSZ 1 - HG 1 - DBA 1 - REF 1 1 DT 1 5 Jun 2004 RESZ 343 ID|FBpp0071532 SYM|Acox57D-p-PA SYN|CG9707-PA ASAL|FBal0128369==Acox57D-p+ DT|5 Jun 2004 |5 Jun 2004 ASGN|FBgn0034628==Acox57D-p REFDSR { RDID|FBrf0166453 |FlyBase Genome Annotators |2004 AAL|677 ASTR|FBtr0071606==Acox57D-p-RA } REF { REFM|FBrf0166453 |FlyBase Genome Annotators |2004 } } # EOR PPR { RETE|ID 1 FBpp0000029 SYM 1 Acp1-P1 AAL 1 135 PSZ 1 17 HG 1 - DBA 1 + REF 1 3 DT 1 1 Oct 2001 RESZ 576 ID|FBpp0000029 SYM|Acp1-P1 SYN|Acp1+P135 ASAL|FBal0074550==Acp1+ DT|1 Oct 2001 |4 Feb 1998 ARGS|FBgn0014454 DARTS|FBtr0079500 ASGN|FBgn0014454==Acp1 REFDSR { RDID|FBrf0080336 |Qiu and Hardin |1995 AAL|135 PSZ|17 ASTR|FBtr0079500==Acp1-RA } REFDSR { RDID|FBrf0104946 |FlyBase |1996- ASTR|FBtr0079500==Acp1-RA } REFDSR { RDID|FBrf0105495 |FlyBase |1992- DBA|NA:S76894 |PA:AAB33567 } REF { REFM|FBrf0080336 |Qiu and Hardin |1995 REFM|FBrf0104946 |FlyBase |1996- REFM|FBrf0105495 |FlyBase |1992- } } # EOR PPR { RETE|ID 1 FBpp0079123 SYM 1 Acp1-PA AAL 1 135 PSZ 1 - HG 1 - DBA 1 - REF 1 1 DT 1 5 Jun 2004 RESZ 282 ID|FBpp0079123 SYM|Acp1-PA SYN|CG7216-PA ASAL|FBal0074550==Acp1+ DT|5 Jun 2004 |5 Jun 2004 ASGN|FBgn0014454==Acp1 REFDSR { RDID|FBrf0166453 |FlyBase Genome Annotators |2004 AAL|135 } REF { REFM|FBrf0166453 |FlyBase Genome Annotators |2004 } } # EOR PPR { RETE|ID 1 FBpp0000030 SYM 1 Acp26Aa-P1 AAL 1 264 PSZ 1 29 HG 1 + DBA 1 + REF 1 5 DT 1 4 Feb 2000 RESZ 3364 ID|FBpp0000030 SYM|Acp26Aa-P1 SYN|Acp26Aa+P264 ASAL|FBal0066337==Acp26Aa+ DT|4 Feb 2000 |4 Feb 1998 ARGS|FBgn0002855 DARTS|FBtr0079155 ASGN|FBgn0002855==Acp26Aa REFDSR { RDID|FBrf0048092 |Monsma and Wolfner |1988 AAL|264 PSZ|29 | predicted |41 | observed |37 | observed |36 | observed HG|Aplysia californica | ELH ABOD|polyclonal DBA|NA:Y00219 |PA:CAA68366 ASTR|FBtr0079155==Acp26Aa-RA CC|FBgn0002855==Acp26Aa protein contains a signal sequence and 5 pairs of basic amino | acids that may be sites of specific peptidase cleavage. It is thought to be | a secreted protein which is glycosylated and cleaved into smaller peptides. | Results show that it is transferred to the female genital tract upon | mating. One stretch of the FBgn0002855==Acp26Aa amino acid sequence is similar to the | Aplysia egg-laying hormone (11 or 17 amino acids identical). } REFDSR { RDID|FBrf0051522 |Monsma et al. |1990 BODP|FBgn0002855==Acp26Aa protein is not detectable in stage P13 pupae but is detectable in | accessory glands dissected from adult males 3-4 hours after eclosion. | Levels reach a plateau about 3-5 days after eclosion. Levels remain high in | accessory gland secretions, even in 30 day old virgin males. Staining is | present in both the main cells and the secondary cells. In 5 day and older | virgin males, protein is absent in the main cells but is present in the | secondary cells where it is concentrated in large vesicles. Abundance of | FBgn0002856==Acp26Ab protein is stimula ed by copulation. FBgn0002855==Acp26Aa protein is | detected in the female genital tract 10 minutes after the start of | copulation as well as in the hemolymph. Levels in the hemolymph decrease | with time. It is still detected at 6 hours but not at 24 hours after | copulation. In the female genital tract, it is present as a 30kD processed | form by the end of copulation. By 30 minutes after the end of copulation, | it is found predominantly as a 25kD form. Less abundant 33kD and 28kD bands | may be further processing intermediates. By 2 hours, only the 25kD form is | detected. It is still detected by 3 hours but not t 4 hours after | copulation. Protein was not detected in any other tissue examined. The 25kD | form was shown to contain the ELH-similar region of the protein. CVBODP|immunolocalization | A | male male accessory gland

| A | male male accessory gland main cell

| A | male male accessory gland secondary cell

| A | female adult hemolymph

| A | female genital chamber

CC|FBgn0002855==Acp26Aa protein was found to contain carbohydrates. } REFDSR { RDID|FBrf0084252 |Park and Wolfner |1995 ABOD|polyclonal CC|Antibodies were prepared against the carboxy-terminal portion of the protein | (amino acids 250-264), the amino terminus (amino acids 1-64) and the middle | (amino acids 76-121). } REFDSR { RDID|FBrf0104946 |FlyBase |1996- ASTR|FBtr0079155==Acp26Aa-RA } REFDSR { RDID|FBrf0105495 |FlyBase |1992- DBA|NA:Y00219 |PA:CAA68366 } REF { REFM|FBrf0048092 |Monsma and Wolfner |1988 REFM|FBrf0051522 |Monsma et al. |1990 REFM|FBrf0084252 |Park and Wolfner |1995 REFM|FBrf0104946 |FlyBase |1996- REFM|FBrf0105495 |FlyBase |1992- } } # EOR PPR { RETE|ID 1 FBpp0078786 SYM 1 Acp26Aa-PA AAL 1 264 PSZ 1 - HG 1 - DBA 1 - REF 1 1 DT 1 5 Jun 2004 RESZ 291 ID|FBpp0078786 SYM|Acp26Aa-PA SYN|CG8982-PA ASAL|FBal0066337==Acp26Aa+ DT|5 Jun 2004 |5 Jun 2004 ASGN|FBgn0002855==Acp26Aa REFDSR { RDID|FBrf0166453 |FlyBase Genome Annotators |2004 AAL|264 } REF { REFM|FBrf0166453 |FlyBase Genome Annotators |2004 } } # EOR PPR { RETE|ID 1 FBpp0002331 SYM 1 Acp26Aa+P25kD AAL 1 - PSZ 1 25 HG 1 - DBA 1 - REF 1 2 DT 1 22 Jun 1999 RESZ 1085 ID|FBpp0002331 SYM|Acp26Aa+P25kD SYN|AcpAa+P25kD ASAL|FBal0066337==Acp26Aa+ DT|22 Jun 1999 |28 Jul 1998 ID2|FBpp0002321 ASGN|FBgn0002855==Acp26Aa REFDSR { RDID|FBrf0051522 |Monsma et al. |1990 PRG|FBpp0002320==Acp26Aa+P30kD MOD|proteolytic processing PSZ|22 | observed BODP|The 25kD processed form of FBgn0002855==Acp26Aa protein is the major form in the female | genital tract 30 minutes after mating, and by 2 hours, it is the only form detected. CVBODP|immunolocalization | A | female genital chamber

} REFDSR { RDID|FBrf0084252 |Park and Wolfner |1995 PRG|FBpp0002320==Acp26Aa+P30kD PSZ|25 | observed BODP|The processed forms of FBgn0002855==Acp26Aa protein are detected in the female genital tract. CVBODP| A | female genital chamber

CC|Generated from the 30kD species by an N-terminal cleavage step in the female | genital tract. } REF { REFM|FBrf0051522 |Monsma et al. |1990 REFM|FBrf0084252 |Park and Wolfner |1995 } } # EOR PPR { RETE|ID 1 FBpp0002330 SYM 1 Acp26Aa+P28kD AAL 1 - PSZ 1 28 HG 1 - DBA 1 - REF 1 1 DT 1 13 May 1999 RESZ 565 ID|FBpp0002330 SYM|Acp26Aa+P28kD SYN|Acp26Aa+28PkD ASAL|FBal0066337==Acp26Aa+ DT|13 May 1999 |28 Jul 1998 ASGN|FBgn0002855==Acp26Aa REFDSR { RDID|FBrf0084252 |Park and Wolfner |1995 PSZ|28 | observed BODP|The processed forms of FBgn0002855==Acp26Aa protein are detected in the female genital tract. CVBODP| A | female genital chamber

CC|Generated from a 33kD species by an N-terminal cleavage step in the female | genital tract. } REF { REFM|FBrf0084252 |Park and Wolfner |1995 } } # EOR PPR { RETE|ID 1 FBpp0002320 SYM 1 Acp26Aa+P30kD AAL 1 - PSZ 1 30 HG 1 - DBA 1 - REF 1 2 DT 1 28 Jul 1998 RESZ 1258 ID|FBpp0002320 SYM|Acp26Aa+P30kD ASAL|FBal0066337==Acp26Aa+ DT|28 Jul 1998 |28 Jul 1998 ASGN|FBgn0002855==Acp26Aa REFDSR { RDID|FBrf0051522 |Monsma et al. |1990 PRG|FBpp0002327==Acp26Aa+P37kD MOD|proteolytic processing PSZ|29 | observed BODP|The 30kD processed form of FBgn0002855==Acp26Aa protein is the major form in the female | genital tract by the end of mating. CVBODP|immunolocalization | A | female genital chamber

CC|Three forms of FBgn0002855==Acp26Aa protein are present in the male accessory gland, | 36, 37, and 41kD. The 37kD is the most abundant. This is cleaved to 30kD in | the female genital tract by the end of mating. There may be a 33kD intermediate. } REFDSR { RDID|FBrf0084252 |Park and Wolfner |1995 PRG|FBpp0002329==Acp26Aa+P33kDB PSZ|30 | observed BODP|The processed forms of FBgn0002855==Acp26Aa protein are detected in the female genital tract. CVBODP| A | female genital chamber

CC|Generated from a 33kD species by an N-terminal cleavage step in the female | genital tract. } REF { REFM|FBrf0051522 |Monsma et al. |1990 REFM|FBrf0084252 |Park and Wolfner |1995 } } # EOR PPR { RETE|ID 1 FBpp0002328 SYM 1 Acp26Aa+P33kDA AAL 1 - PSZ 1 33 HG 1 - DBA 1 - REF 1 1 DT 1 28 Jul 1998 RESZ 644 ID|FBpp0002328 SYM|Acp26Aa+P33kDA ASAL|FBal0066337==Acp26Aa+ DT|28 Jul 1998 |28 Jul 1998 ASGN|FBgn0002855==Acp26Aa REFDSR { RDID|FBrf0084252 |Park and Wolfner |1995 PRG|FBpp0002326==Acp26Aa+P38kD MOD|proteolytic processing PSZ|33 | observed BODP|The processed forms of FBgn0002855==Acp26Aa protein are detected in the female genital tract. CVBODP| A | female genital chamber

CC|Thought to be generated from a putative 38kD product by an N-terminal | cleavage step in the female genital tract. } REF { REFM|FBrf0084252 |Park and Wolfner |1995 } } # EOR PPR { RETE|ID 1 FBpp0002329 SYM 1 Acp26Aa+P33kDB AAL 1 - PSZ 1 33 HG 1 - DBA 1 - REF 1 1 DT 1 28 Jul 1998 RESZ 623 ID|FBpp0002329 SYM|Acp26Aa+P33kDB ASAL|FBal0066337==Acp26Aa+ DT|28 Jul 1998 |28 Jul 1998 ASGN|FBgn0002855==Acp26Aa REFDSR { RDID|FBrf0084252 |Park and Wolfner |1995 PRG|FBpp0002327==Acp26Aa+P37kD MOD|proteolytic processing PSZ|33 | observed BODP|The processed forms of FBgn0002855==Acp26Aa protein are detected in the female genital tract. CVBODP| A | female genital chamber

CC|Generated from the 37kD species by an N-terminal cleavage step in the female | genital tract. } REF { REFM|FBrf0084252 |Park and Wolfner |1995 } } # EOR PPR { RETE|ID 1 FBpp0002327 SYM 1 Acp26Aa+P37kD AAL 1 - PSZ 1 37 HG 1 - DBA 1 - REF 1 1 DT 1 28 Jul 1998 RESZ 1111 ID|FBpp0002327 SYM|Acp26Aa+P37kD ASAL|FBal0066337==Acp26Aa+ DT|28 Jul 1998 |28 Jul 1998 ASGN|FBgn0002855==Acp26Aa REFDSR { RDID|FBrf0084252 |Park and Wolfner |1995 PSZ|37 | observed CC|The 41kD, 37kD and 36kD forms of FBgn0002855==Acp26Aa protein differ in the extent of | glycosylation. The 36kD species is far less abundant than the other two. By | tracking with region-specific antibodies, it was shown that the 41kD | species is processed to 38kD, 33kD and finally to 28kD while the 37kD | species is processed to 33kD, 30kD and finally 25kD in parallel processing | pathways. These processing steps were shown to consist of stepwise cleavage | events in the N-terminal half of the protein. The processing sites were | mapped by CNBr mapping and by analysis of conservated cle vage sites within | several Drosophila species. Finally, it was found that accessory gland main | cell secretions are necessary to process FBgn0002855==Acp26Aa protein in the female | genital tract. } REF { REFM|FBrf0084252 |Park and Wolfner |1995 } } # EOR PPR { RETE|ID 1 FBpp0002326 SYM 1 Acp26Aa+P38kD AAL 1 - PSZ 1 - HG 1 - DBA 1 - REF 1 1 DT 1 28 Jul 1998 RESZ 515 ID|FBpp0002326 SYM|Acp26Aa+P38kD ASAL|FBal0066337==Acp26Aa+ DT|28 Jul 1998 |28 Jul 1998 ASGN|FBgn0002855==Acp26Aa REFDSR { RDID|FBrf0084252 |Park and Wolfner |1995 PRG|FBpp0002325==Acp26Aa+P41kD MOD|proteolytic processing CC|This putative cleavage product was not detected. It is thought to be | generated from the 41kD product by an N-terminal cleavage step in the | female genital tract. } REF { REFM|FBrf0084252 |Park and Wolfner |1995 } } # EOR PPR { RETE|ID 1 FBpp0002325 SYM 1 Acp26Aa+P41kD AAL 1 - PSZ 1 41 HG 1 - DBA 1 - REF 1 1 DT 1 28 Jul 1998 RESZ 1109 ID|FBpp0002325 SYM|Acp26Aa+P41kD ASAL|FBal0066337==Acp26Aa+ DT|28 Jul 1998 |28 Jul 1998 ASGN|FBgn0002855==Acp26Aa REFDSR { RDID|FBrf0084252 |Park and Wolfner |1995 PSZ|41 | observed CC|The 41kD, 37kD and 36kD forms of FBgn0002855==Acp26Aa protein differ in the extent of | glycosylation. The 36kD species is far less abundant than the other two. By | tracking with region-specific antibodies, it was shown that the 41kD | species is processed to 38kD, 33kD and finally to 28kD while the 37kD | species is processed to 33kD, 30kD and finally 25kD in parallel processing | pathways. These processing steps were shown to consist of stepwise cleavage | events in the N-terminal half of the protein. The processing sites were | mapped by CNBr mapping and by analysis of conserved cleav ge sites within | several Drosophila species. Finally, it was found that accessory gland main | cell secretions are necessary to process FBgn0002855==Acp26Aa protein in the female | genital tract. } REF { REFM|FBrf0084252 |Park and Wolfner |1995 } } # EOR PPR { RETE|ID 1 FBpp0000031 SYM 1 Acp26Ab-P1 AAL 1 90 PSZ 1 10 HG 1 - DBA 1 + REF 1 4 DT 1 4 Feb 2000 RESZ 2304 ID|FBpp0000031 SYM|Acp26Ab-P1 SYN|Acp26Ab+P90 ASAL|FBal0066338==Acp26Ab+ DT|4 Feb 2000 |4 Feb 1998 ARGS|FBgn0002856 DARTS|FBtr0079156 |FBtr0079157 ASGN|FBgn0002856==Acp26Ab REFDSR { RDID|FBrf0048092 |Monsma and Wolfner |1988 AAL|90 PSZ|10 | predicted |11-14 | observed ABOD|polyclonal DBA|NA:Y00219 |PA:CAA68367 ASTR|FBtr0002675==Acp26Ab+R0.5 CC|FBgn0002856==Acp26Ab protein has a signal sequence and is a potential secreted protein. | Results show that it is transferred to the female genital tract upon mating. } REFDSR { RDID|FBrf0051522 |Monsma et al. |1990 BODP|FBgn0002856==Acp26Ab protein is not detectable in stage P13 pupae but is detectable in | accessory glands dissected from adult males 3-4 hours after eclosion. | Levels reach a plateau about 3-5 days after eclosion. Levels remain high in | accessory gland secretions, even in 30 day old virgin males. Staining is | present in both the main cells and the secondary cells of the accessory | gland. In 5 day and older virgin males, protein is absent in the main cells | but is present in the secondary cells where it is concentrated in large | vesicles. Abundance of Acp2 Ab protein is stimulated by copulation. | FBgn0002856==Acp26Ab protein is detected in the female genital tract 10 minutes after | the start of copulation as well as in the hemolymph. It is no longer | detected in the hemolymph by 2 hours after copulation and in the female | genital tract by 2-3 hours after copulation. Protein was not detected in | any other tissue examined. ASM|immunolocalization CVBODP|immunolocalization | A | male male accessory gland

| A | male male accessory gland main cell

| A | male male accessory gland secondary cell

| A | female adult hemolymph

| A | female genital chamber

CVCEL|cytoplasm } REFDSR { RDID|FBrf0104946 |FlyBase |1996- ASTR|FBtr0079156==Acp26Ab-RA |FBtr0079157==Acp26Ab-RB } REFDSR { RDID|FBrf0105495 |FlyBase |1992- DBA|NA:Y00219 |PA:CAA68367 } REF { REFM|FBrf0048092 |Monsma and Wolfner |1988 REFM|FBrf0051522 |Monsma et al. |1990 REFM|FBrf0104946 |FlyBase |1996- REFM|FBrf0105495 |FlyBase |1992- } } # EOR PPR { RETE|ID 1 FBpp0078787 SYM 1 Acp26Ab-PA AAL 1 90 PSZ 1 - HG 1 - DBA 1 - REF 1 1 DT 1 5 Jun 2004 RESZ 290 ID|FBpp0078787 SYM|Acp26Ab-PA SYN|CG9024-PA ASAL|FBal0066338==Acp26Ab+ DT|5 Jun 2004 |5 Jun 2004 ASGN|FBgn0002856==Acp26Ab REFDSR { RDID|FBrf0166453 |FlyBase Genome Annotators |2004 AAL|90 } REF { REFM|FBrf0166453 |FlyBase Genome Annotators |2004 } } # EOR PPR { RETE|ID 1 FBpp0078788 SYM 1 Acp26Ab-PB AAL 1 90 PSZ 1 - HG 1 - DBA 1 - REF 1 1 DT 1 5 Jun 2004 RESZ 290 ID|FBpp0078788 SYM|Acp26Ab-PB SYN|CG9024-PB ASAL|FBal0066338==Acp26Ab+ DT|5 Jun 2004 |5 Jun 2004 ASGN|FBgn0002856==Acp26Ab REFDSR { RDID|FBrf0166453 |FlyBase Genome Annotators |2004 AAL|90 } REF { REFM|FBrf0166453 |FlyBase Genome Annotators |2004 } } # EOR PPR { RETE|ID 1 FBpp0079321 SYM 1 Acp29AB-PA AAL 1 234 PSZ 1 - HG 1 - DBA 1 - REF 1 1 DT 1 5 Jun 2004 RESZ 336 ID|FBpp0079321 SYM|Acp29AB-PA SYN|CG17797-PA ASAL|FBal0075464==Acp29AB+ DT|5 Jun 2004 |5 Jun 2004 ASGN|FBgn0015583==Acp29AB REFDSR { RDID|FBrf0166453 |FlyBase Genome Annotators |2004 AAL|234 ASTR|FBtr0079716==Acp29AB-RA } REF { REFM|FBrf0166453 |FlyBase Genome Annotators |2004 } } # EOR PPR { RETE|ID 1 FBpp0003115 SYM 1 Acp29AB+P234 AAL 1 234 PSZ 1 - HG 1 - DBA 1 + REF 1 1 DT 1 16 Aug 2000 RESZ 351 ID|FBpp0003115 SYM|Acp29AB+P234 ASAL|FBal0075464==Acp29AB+ DT|16 Aug 2000 |16 Aug 2000 ASGN|FBgn0015583==Acp29AB REFDSR { RDID|FBrf0100648 |Wolfner et al. |1997 AAL|234 DBA|NA:U85758 |PA:AAB96382 ASTR|FBtr0005947==Acp29AB+R0.95 } REF { REFM|FBrf0100648 |Wolfner et al. |1997 } } # EOR PPR { RETE|ID 1 FBpp0003119 SYM 1 Acp32CD-P1 AAL 1 - PSZ 1 - HG 1 - DBA 1 + REF 1 2 DT 1 14 Dec 2000 RESZ 501 ID|FBpp0003119 SYM|Acp32CD-P1 SYN|Acp32CD+PA ASAL|FBal0087451==Acp32CD+ DT|14 Dec 2000 |16 Aug 2000 ARGS|FBgn0023415 DARTS|FBtr0080158 ASGN|FBgn0023415==Acp32CD REFDSR { RDID|FBrf0100648 |Wolfner et al. |1997 DBA|NA:U90948 |PA:AAB96395 ASTR|FBtr0080158==Acp32CD-RA } REFDSR { RDID|FBrf0104946 |FlyBase |1996- ASTR|FBtr0080158==Acp32CD-RA } REF { REFM|FBrf0100648 |Wolfner et al. |1997 REFM|FBrf0104946 |FlyBase |1996- } } # EOR PPR { RETE|ID 1 FBpp0079747 SYM 1 Acp32CD-PA AAL 1 252 PSZ 1 - HG 1 - DBA 1 - REF 1 1 DT 1 5 Jun 2004 RESZ 291 ID|FBpp0079747 SYM|Acp32CD-PA SYN|CG4605-PA ASAL|FBal0087451==Acp32CD+ DT|5 Jun 2004 |5 Jun 2004 ASGN|FBgn0023415==Acp32CD REFDSR { RDID|FBrf0166453 |FlyBase Genome Annotators |2004 AAL|252 } REF { REFM|FBrf0166453 |FlyBase Genome Annotators |2004 } } # EOR PPR { RETE|ID 1 FBpp0002972 SYM 1 Acp33A-P1 AAL 1 47 PSZ 1 - HG 1 - DBA 1 + REF 1 2 DT 1 16 Aug 2000 RESZ 546 ID|FBpp0002972 SYM|Acp33A-P1 ASAL|FBal0087450==Acp33A+ DT|16 Aug 2000 |11 Apr 2000 ARGS|FBgn0023414 DARTS|FBtr0005637 ASGN|FBgn0023414==Acp33A REFDSR { RDID|FBrf0100648 |Wolfner et al. |1997 AAL|47 DBA|NA:U85763 |PA:AAB96397 ASTR|FBtr0005637==Acp33A-RA CC|One of two possible ORFs encoded by the same transcript. } REFDSR { RDID|FBrf0104946 |FlyBase |1996- AAL|47 ASTR|FBtr0005637==Acp33A-RA } REF { REFM|FBrf0100648 |Wolfner et al. |1997 REFM|FBrf0104946 |FlyBase |1996- } } # EOR PPR { RETE|ID 1 FBpp0002973 SYM 1 Acp33A-P2 AAL 1 43 PSZ 1 - HG 1 - DBA 1 + REF 1 2 DT 1 16 Aug 2000 RESZ 546 ID|FBpp0002973 SYM|Acp33A-P2 ASAL|FBal0087450==Acp33A+ DT|16 Aug 2000 |11 Apr 2000 ARGS|FBgn0023414 DARTS|FBtr0005637 ASGN|FBgn0023414==Acp33A REFDSR { RDID|FBrf0100648 |Wolfner et al. |1997 AAL|43 DBA|NA:U85765 |PA:AAB96390 ASTR|FBtr0005637==Acp33A-RA CC|One of two possible ORFs encoded by the same transcript. } REFDSR { RDID|FBrf0104946 |FlyBase |1996- AAL|43 ASTR|FBtr0005637==Acp33A-RA } REF { REFM|FBrf0100648 |Wolfner et al. |1997 REFM|FBrf0104946 |FlyBase |1996- } } # EOR PPR { RETE|ID 1 FBpp0003113 SYM 1 Acp36DE-P1 AAL 1 - PSZ 1 - HG 1 - DBA 1 + REF 1 2 DT 1 14 Nov 2001 RESZ 501 ID|FBpp0003113 SYM|Acp36DE-P1 SYN|Acp36DE+PA ASAL|FBal0066339==Acp36DE+ DT|14 Nov 2001 |16 Aug 2000 ARGS|FBgn0011559 DARTS|FBtr0081054 ASGN|FBgn0011559==Acp36DE REFDSR { RDID|FBrf0100648 |Wolfner et al. |1997 DBA|NA:U85759 |PA:AAB96383 ASTR|FBtr0081054==Acp36DE-RA } REFDSR { RDID|FBrf0104946 |FlyBase |1996- ASTR|FBtr0081054==Acp36DE-RA } REF { REFM|FBrf0100648 |Wolfner et al. |1997 REFM|FBrf0104946 |FlyBase |1996- } } # EOR PPR { RETE|ID 1 FBpp0080607 SYM 1 Acp36DE-PA AAL 1 912 PSZ 1 - HG 1 - DBA 1 - REF 1 1 DT 1 5 Jun 2004 RESZ 291 ID|FBpp0080607 SYM|Acp36DE-PA SYN|CG7157-PA ASAL|FBal0066339==Acp36DE+ DT|5 Jun 2004 |5 Jun 2004 ASGN|FBgn0011559==Acp36DE REFDSR { RDID|FBrf0166453 |FlyBase Genome Annotators |2004 AAL|912 } REF { REFM|FBrf0166453 |FlyBase Genome Annotators |2004 } } # EOR PPR { RETE|ID 1 FBpp0002974 SYM 1 Acp53Ea-P1 AAL 1 120 PSZ 1 - HG 1 - DBA 1 + REF 1 2 DT 1 16 Aug 2000 RESZ 493 ID|FBpp0002974 SYM|Acp53Ea-P1 ASAL|FBal0075465==Acp53Ea+ DT|16 Aug 2000 |11 Apr 2000 ARGS|FBgn0015584 DARTS|FBtr0087080 ASGN|FBgn0015584==Acp53Ea REFDSR { RDID|FBrf0100648 |Wolfner et al. |1997 AAL|120 DBA|NA:U85758 |PA:AAB96384 ASTR|FBtr0087080==Acp53Ea-RA } REFDSR { RDID|FBrf0104946 |FlyBase |1996- AAL|120 ASTR|FBtr0087080==Acp53Ea-RA } REF { REFM|FBrf0100648 |Wolfner et al. |1997 REFM|FBrf0104946 |FlyBase |1996- } } # EOR PPR { RETE|ID 1 FBpp0086228 SYM 1 Acp53Ea-PA AAL 1 120 PSZ 1 - HG 1 - DBA 1 - REF 1 1 DT 1 5 Jun 2004 RES