transcription factor - homeodomain - Antp class - involved in head and brain morphogenesis - in the midgut Labial plays a role in determination and differentiation of copper cells
transcription factors - homeodomain proteins -overlaps expression of wingless in the epidermis - ladybird genes contribute to the segmentation process and are considered as segment polarity genes
an intermediate filament protein - chromatin associated protein - Lamin binds to scaffold/matrix-associated regions, DNA sequences that are held responsible for mediating the interaction between the nuclear matrix and chromatin.
kinase - regulates cell cycle - loss of gene function leads to the cell-autonomous formation of epithelial tumors in the adult integumentary structures derived from imaginal discs.
ORC3 homolog - regulates DNA replication - also, a presynaptic protein with a role in the Ca2+-dependent synaptic modulation mechanisms necessary for behavioral plasticity
coiled-coil cytoskeletal component involved in cellularization - analysis shows that active Golgi-derived membrane vesicle secretion is essential for cytokinesis
a MAP kinase kinase targeting p38 MAP kinase - licorne mutations provoke polarity defects in the eggshell and embryo, as a result of reduced activity of two localized determinants: Oskar and Gurken
transcription factor - Fragile X mental retardation 2 (Fmr2) family - Functions in MAPK and Dpp signaling pathways - affects growth, a function associated with the insulin pathway - affects the cytoskeleton early in development.
Lim domain and lim homeodomain protein - expressed in the head primordia, the brain lobes, and in distinct sets of motorneurons and interneurons within the ventral nerve cord - Lim1 larval mutants have abnormal motor coordination
component of Dynein complex, Beta-transducin family Trp-Asp repeats protein - required in the germline for synchronized cystocyte division and oocyte differentiation
regulators of G-protein signalling (RGS) protein - a GTPase-activating protein (GAP) acting on alpha subunit of G-proteins - Mutant glial cells fail to properly ensheath longitudinal axon tracts and do not form the normal glial-glial cell contacts, resulting in a disruption of the blood-brain barrier
DEAH-box subfamily ATP-dependent helicase - Mle plays an early role in dosage compensations, perhaps in packaging roX2 RNA into growing dosage compensation protein complexes
Component of Epidermal growth factor receptor signaling pathway - involved in establishment of the dorsoventral polarity of the egg shell and the embryo - acts in specification of terminal structures immediately after fertilization - Gain-of-function mutants produce extra R7 photoreceptors and extra wing veins
transcription factor - stat homolog - cytoplasmic signal transducing protein - regulates the even-skipped stripe 3 promoter and the pair rule gene runt - central to the establishment of planar polarity during Drosophila eye development
Smad family member - associates with Smad1 in response to BMP2/4 or with Smad2 in response to TGF-beta - dominant negative Smad4 blocks both BMP and activin responses
ATM/ATR kinase, phosphatidylinositol 3-kinase - essential for the DNA damage checkpoint in larval imaginal discs and neuroblasts - required to delay mitosis in response to incomplete DNA replication in early nuclear divisions - monitors double-strand-break repair during meiotic crossing over
serine/threonine kinase - mutants show an inabillity to generate a sufficient number of optic lobe and central brain neurons during postembryonic development
minifly (preferred name: Nucleolar protein at 60B)
pseudouridylate synthase - enzymatically modifies ribosomal RNA - required for maintenance of germ-line stem cells
novel - required for subcellular localization of prospero - a target of the asymmetric cell division machinery - involved in the generation of cell diversity in the CNS
RNA binding protein - Notch signaling regulate Msi activity as a translational repressor of Tramtrack in the generation of non-neuronal lineages in during bristle development
Death domain protein - Encodes an essential component of the Toll pathway in dorsoventral pattern formation - involved in signal transduction in the immune response
transmembrane - integrin-beta subunit of PS1 & PS2 - Integrins are used to attach mesoderm to ectoderm and are required for the proper assembly of the extracellular matrix and for muscle attachment
developmentally regulated N-ethylmaleimide-sensitive fusion (NSF) gene - mutants are defective in the synaptic
growth and maturation that occurs during larval development
IG superfamily - NgCAM related - a cell aggregaton and signaling molecule that transmits the positional value of cell adhesion to the cytoplasmic assembly of ankyrin and spectrin
transmembrane serine esterase homolog - Mutations in Neurotactin
frequently cause defasciculation of the normally tightly associated ocellar pioneer axons
Ca++/Calmodulin sensitive enzyme - ectopic expression of NOS at the late stages of larval development results in a decrease in cell proliferation and a reduction in the size of the adult fly's structures
NK1 (preferred name: slouch, common alternative name: S59)
transcription factor - homeodomain - NK-1 class - maintenance of slouch is directly involved in the control of late aspects of muscle development, such as muscle differentiation and morphogenesis, and possibly also innervation
NK2 (preferred name: ventral nervous system defective)
transcription factor - homeodomain - NK2 class - required for the formation of a subset of segmental neuroblasts, and possibly as a neuroectodermal committment gene - upstream of proneural achaete-scute complex.
A subunit of the Origin recognition complex, regulating the initiation of DNA replication - Orc1 is degraded by APC at the cell's exit from mitosis and reaccumulates at the end of G1
transcription factor - homeodomain - paired-like - acts in a combinatorial fashion with the cephalic gap genes empty spiracles and buttonhead to assign segmental identities in the head and brain
a novel ligand - potential activator of JAK/STAT signaling pathway - mutation results in the stripe-specific loss of expression of even-skipped, fushi tarazu, and runt
novel protein required in oogenesis - ensures the survival of female germ cells in pupae, cyst formation in germ-line cells, the attainment of mature chromosome structure in nurse cells and egg maturation.
transcription factor - homeodomain - paired domain - plays a decisive role in the progression of a regulatory hierarchy from pair-rule directed segmentation of the embryo to the subdivision carried out by segment polarity genes specifying positional information within segments
transcription factor - zinc finger - GATA family - a local repressor of achaete and scute - required for the normal pattern of sensory bristles in those parts of the dorsal epithelium
PAR-domain bZIP transcription factor - controls skeletal muscle genes during differentiation - regulates expression of the Tropomyosin I gene in somatic body-wall and pharyngeal muscles
ubiquitin protein ligase - degrades proteins with aberrant conformations - mutants exhibit muscle degeneration, male sterility, and defects in brain dopaminergic cells
a kinesin motor protein - required both to establish the structure of the telophase spindle to provide a framework for assembly of the contractile ring and to mobilize mitotic regulator proteins
transcription factor - homeodomain and pou domain - collaborates with nubbin/pdm-1 during specification of the RP2/sib lineage in Drosophila neurogenesis
an enzyme involved in producing amidated neuropeptides - amidated secretory peptides are required for signaling
events that ensure progression through several critical developmental transitions
subunit of the epithelial sodium channel (ENaC) family - plays an essential role in controlling rhythmic locomotion by providing mechanosensory signal transduction of proprioceptive sensory information
novel protein required for sister chromatid separation in mitosis - shares functional similarities to securin a protein that acts to premature activation of separins
zinc finger - Polycomb group - the first Polycomb group member to be identified as a DNA binding protein - targets Polycomb response elements involved in gene silencing
transcription factor - ets family - a target of Egf signaling - required for the differentiation of glial cells in the ventral nerve cord - required downstream of Ras in the development of the eye
pokkuri(preferred name: anterior open, common alternative name: yan)
ets domain transcription factor - target of Ras pathway that serves to inhibit neural and other types of differentiation
transcription factor - zinc finger - Polycomb group - maintain the repression of hedgehog in the anterior cells abutting the anterior-posterior boundary of the developing wing
transcription factor - zn finger-ring motif-Polycomb group - Psc is a component of Suppressor of zeste 2 complex - recruits functional PcG-silencing complexes
transcription factor - homeodomain and pou domain - along with pdm-1 involved in cell fate determination of a subset of temporally determined neural subtypes
serine/threonine kinase, diacylglycerol binding protein - flies expressing a PKC pseudosubstrate show an alteration in performance in courtship conditioning; they fail to show immediate suppression of courtship, a trait exhibited by normal flies
B subunit of PP2A - four independent defects have been associated with mutant PP2A; defective mitosis, defective cell fate determination in the PNS, alteration of patterning in the wing, and interferance in Ras pathway function in eye morphogenesis
Set domain protein - methyltransferase that targets Histone H4 - helps maintain silent chromatin by a histone modification that precludes neighboring acetylation of the H4 tail
receptor for Dpp - type II TGFß receptor - punt lack Ultrabithorax and dpp expression in the visceral mesoderm and fail to induce labial in the adjacent endodermal cells
ras homolog - establishes follicular cell fate during oogenesis, functions in Torso signal transduction, functions downstream EGF-R in the establishment of ventral ectoderm fate, functions downstream of Breathless in tracheal and midline glia migration, functions downstream of FGF receptor in muscle precursors and in the central nervous system, functions downstream of the EGF-R and Sevenless in differentiation in photoreceptors
a novel signaling protein that prevents cyclin degredation in G2 by interacting with Fizzy-related - inhibits Fizzy-related's activation of protein degradation machinery - mutants exhibit premature cyclin destruction
Ankyrin-repeat and NFkappaB domain protein - a key factor in the induction of the humoral immune response in Drosophila, including antibacterial as well as antifungal factors
cell cycle regulator - interacts with and negatively regulates members of a family of factors called E2Fs, which serve to activate transcription of genes required for entry into S phase.
Ras superfamily of G-proteins - functions downstream of the tumor suppressors Tsc1 and Tsc2 (Gigas in Drosophila), with Tsc2 functioning as a GAP for Rheb - signals to the growth regulator known as Target of rapamycin (TOR)
rho-subfamily GTPase - in concert with DRhoGEF2, Rho1 mediates specific cell shape changes during gastrulation in response to the extracellular ligand, Folded gastrulation
serine protease - transmembrane protein involved with Epidermal growth factor receptor signaling - required for the production or processing of Spitz, the Egfr ligand
X chomosome associated RNA - chromatin associated non-translated RNA involved in dosage compensation
rolled (common alternative name: MAP kinase or ERKA)
Component of Epidermal growth factor receptor signaling pathway - involved in establishment of the dorsoventral polarity of the egg shell and the embryo - acts in specification of terminal structures immediately after fertilization - Gain-of-function mutants produce extra R7 photoreceptors and extra wing veins
RING-finger motif, ankyrin repeat and TR repeat protein - a signaling protein that interacts with the cytoplasmic domain of Dumbfounded and with Myoblast city - functions to integrate initial myoblast fusion with myotube structural organization
transcription factor - homeodomain - plays a critical role in restriction of the number of photoreceptor precursors in the specification of R8 photoreceptors
novel regulator of cell cycle - a cyclin dependent kinase inhibitor that
specifically inhibits Cdk1-CycA - required to inhibit Cdk1-CycA kinase activity during metaphase, thereby facilitating the transition to anaphase
